Вид документа : Статья из журнала Шифр издания : 61/R 35 Автор(ы) : Gein S. V., Gavrilova T. V., Gein O. N., Nikitina L. S., Chereshneva M. V., Chereshnev V. A., Kirilina E. A. Заглавие : Regulation of the peritoneal macrophage functional activity by the MP-5 and MP-6 myelopeptides under stress Место публикации : Doklady Biological Sciences. - 2017. - Vol. 475, № 1. - С. 154-156 ББК : 61 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): peptides--macrophages--active oxygen Аннотация: In mice, two-hour immobilization stress inhibited zymosan-induced production by macrophages of the oxygen radicals and cytokine IL-1[beta]. After myelopeptides MP-5 and MP-6 were administered into mice, the stress-induced inhibition of the reactive oxygen species (ROS) and IL-1[beta] was abrogated. MP-5 peptide stimulated spontaneous ROS production by macrophages and reduced IL-10 production under stress. Thus, under in vivo conditions and under stress, the effect of MP-5 and MP-6 myelopeptides modulates the peritoneal macrophage activity. Доп.точки доступа: Gein, S. V.; Gavrilova, T. V.; Gein, O. N.; Nikitina, L. S.; Chereshneva, M. V.; Chereshnev, V. A.; Kirilina, E. A.