Вид документа : Статья из журнала Шифр издания : 57/T 44 Автор(ы) : Gein S. V., Baeva T. A., Gein O. N., Chereshnev V. A. Заглавие : The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes Место публикации : Human Physiology. - 2006. - Vol. 32, № 3. - С. 346-350 ББК : 57 Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): monocytes--beta endorphin--blood lymphocytes Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e Доп.точки доступа: Gein, S. V.; Baeva, T. A.; Gein, O. N.; Chereshnev, V. A.