Вид документа : Статья из журнала Шифр издания : Автор(ы) : Saidakova E. V., Korolevskaya L. B., Shmagel N. G., Vlasova V. V., Shardina K. Yu., Chereshnev V. A., Shmagel K. V. Заглавие : In HIV-infected immunological non-responders, hepatitis C virus eradication contributes to incomplete normalization of systemic inflammation, but does not lead to rapid CD4+ T-cell count recovery Место публикации : Doklady Biochemistry and Biophysics. - 2023. - Vol. 512. - С. 274–278 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): hiv infections--hepatitis c--immunological non-response Аннотация: In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antivirals for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected INRs and relatively healthy volunteers. It was established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete. Доп.точки доступа: Saidakova, E. V.; Korolevskaya, L. B.; Shmagel, N. G.; Vlasova, V. V.; Shardina, K. Yu.; Chereshnev, V. A.; Shmagel, K. V.