P 72 Platelet aggregation inhibitor properties of 1,3,4-thiadiazine thiadiazines [Text] / T. M. Vasilyeva, V. A. Makarov, O. N. Chupakhin, L. P. Sidorova, N. M. Perova, V. L. Rusinov // Gematologiya i Transfusiologiya . - 2008. - Vol. 53, № 4. - P12-15. - Bibliogr. : p. 15 (14 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 1,3,4-THIADIAZINES -- PLATELET AGGREGATION -- ARACHIDONIC ACID -- ADP Аннотация: Effects of new 1,3,4-thiadiazines on human platelet aggregation were studied in vitro. All 1,3,4-thiadiazines inhibited aggregation induced by ADP and arachidonic acid in a wide range of concentrations. The most active of the studied 1,3,4-thiadiazines were L-19, L-20, L-25, L-28, and L-31 in concentrations of 0.01-1 mM, effectively reducing platelet aggregation induced by arachidonic acid and ADP. |