F 33 Features of synthesis and structure of ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)-propyl-2-enoate / D. N. Bazhin, E. V. Shchegol'kov, Yu. S. Kudyakova, K. V. Scherbakov, Ya. V. Burgart, V. I. Saloutin // Russian Journal of General Chemistry. - 2012. - Vol. 82, № 1. - С. 116-121. - Bibliogr. : p. 121 (22 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ANTIBACTERIAL AGENTS -- DERIVATIVES -- OFLOXACIN -- ESTERS Аннотация: The structure of key intermediates in the synthesis of fluoroquinolone antibiotics: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate and ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)prop-2-enoate was for first time studied using X-ray diffraction (XRD) and H-1, F-19 NMR spectroscopy. In solution both the esters were shown to exist as a mixture of enol and ketone tautomeric forms with predominance of the latter. According to the XRD analysis, ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)prop-2-enoate in the solid state exists entirely in the enol form \\\\Expert2\\nbo\\Russian Journal of General Chemistry\\2012, V. 82, N 8, p. 1444–1450.pdf |