F 97 Functionalization, cyclization and antiviral activity of A-secotriterpenoids / V. V. Grishko, N. V. Galaiko, I. A. Tolmacheva, O. V. Savinova, P. A. Slepukhin // European Journal of Medicinal Chemisrty. - 2014. - Vol.83. - С. 601-608. - Bibliogr. : p. 608 (37 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 18βH-GLYCYRRHETINIC ACID -- A-SECOTRITERPENOIDS -- ANTIVIRAL ACTIVITY Аннотация: Triterpene derivatives with an α,β-alkenenitrile moiety in the five-membered ring A have been synthesized by nitrile anion cyclizations of 1-cyano-2,3-secotriterpenoids. Oxime-containing precursors, 2,3- secointermediates and five-membered ring A products of cyclizations were screened for in vitro antiviral activity against enveloped viruses - influenza A virus and human immunodeficiency virus type I (HIV-1). Lupane ketoxime and the 2,3-secolupane C-3 aldoxime which possess antiviral activities against both influenza A virus (EC50 12.9-18.2 μM) and HIV-1 (EC50 0.06 μM) were the most promising compounds. \\\\expert2\\nbo\\European Journal of Medicinal Chemistry\\2014, v.83, p.601-608.pdf |