A 89 Asymmetric Biginelli Reaction Catalyzed by Silicon, Titanium and Aluminum Oxides [Electronic resource] / O. V. Fedorova, Yu. A. Titova, A. Yu. Vigorov, M. S. Toropova, O. A. Alisienok, A. Murashkevich, V. P. Krasnov, G. L. Rusinov, V. N. Charushin // Catalysis Letters. - 2016. - Vol.146, № 2. - С. 493-498 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): BIGINELLI REACTION -- PHENYLETHYLAMINE -- ALUMINUM OXIDES Аннотация: The asym. Biginelli reaction was investigated in the presence of N-[(2S,4R)-4-hydroxyprolyl]-(S)-1-phenylethylamine as chiral inducer and silicon, titanium or aluminum oxides (individual and mixed, bulk and nanosized) as heterogeneous catalysts. The synthesis of Et (4R)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate from benzaldehyde, urea and Et acetoacetate has been described. It has been shown that all studied oxides improve chemo- and stereoselectivity of the Biginelli reaction. \\\\expert2\\nbo\\Catalysis Letters\\2016, v.146, p.493.pdf |