S 98 Synthesis of new efficient and selective carboxylesterase inhibitors based on adamantyl and citronellyl 4,4,4-trifluoro-2-arylhydrazonylidene-3-oxobutanoates / N. A. Elkina, E. V. Shchegolkov, Ya. V. Burgart [et al.] // Russian chemical bulletin. - 2021. - Vol. 70, № 3. - P567–572 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 4,4,4-TRIFLUORO-2-ARYLHYDRAZINYLIDENE-3-OXOBUTANOATES -- NATURAL ALCOHOLS -- CARBOXYLESTERASE -- INHIBITORS -- MOLECULAR DOCKING Аннотация: A series of new adamantyl and citronellyl 4,4,4-trifluoro-2-arylhydrazinylidene-3-oxo-butanoates was synthesized. The synthesized compounds in nanomolar concentrations selectively inhibit carboxylesterase, while their activity is independent of the nature and position of the substituent in the aryl fragment, which is consistent with the molecular docking results. |