Synthesis and tuberculostatic activity of new 3-alkylthio-6-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines / R. I. Ishmetova, I. N. Ganebnykh, N. K. Ignatenko [et al.] // Russian chemical bulletin. - 2021. - Vol. 70, № 6. - P1093-1098 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): [1,2,4]TRIAZOLO[4,3-B][1,2,4,5]TETRAZINES -- N-NUCLEOPHILES -- CYCLIZATION -- TUBERCULOSTATIC ACTIVITY Аннотация: A number of new 3-alkylthio-6-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazines were synthesized and modifi ed in nucleophilic substitution reactions with aliphatic amines. The study of the tuberculostatic activity of the compounds obtained revealed a number of active derivatives with a minimum inhibitory concentration of 0.37—3.1 mg mL–1. |