Multicomponent domino reactions for the synthesis of variable hydrogenated imidazo[1,2-a]pyridines / S. O. Kushch, M. V. Goryaeva, E. A. Surnina [et al.] // Asian journal of organic chemistry. - 2021. - № 11. - Pe2021007 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Autocatalyzed one-pot multicomponent cyclization of polyfluoroalkyl-3-oxo ester and ethylenediamine with aldehyde is an effective approach to octa-, hexa- and tetrahydroimidazo[1,2-a]pyridines generated mainly due to the α,β-unsaturated aldehyde addition, often formed in situ, to the 3-oxo ester methylene fragment, followed by the pyridine backbone closure at one of the carbonyl groups. |