Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs / S. O. Kushch, M. V. Goryaeva, Ya. V. Burgart [et al.]> // Russian chemical bulletin. - 2022. - Vol. 71, № 8. - P1687-1700 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity. |