Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Kotovskaya S. K., Baskakova Z. M., Charushin V. N., Chupakhin O. N., Belanov E. F., Bormotov N. I., Balakhnin S. M., Serova O. A. Заглавие : Synthesis and antiviral activity of fluorinated pyrido[1,2-a]benzimidazoles [Electronic resource] Место публикации : Pharmaceutical Chemistry Journal. - 2005. - Vol. 39, № 11. - С. 574-578 Систем. требования: http://www.springerlink.com/content/58722p2385288304/fulltext.pdf Примечания : Библиогр. : с. 578 (16 назв.). - 1.11.2011 г. ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Methods for the synthesis of fluorinated pyrido[1,2-a]benzimidazoles have been developed, and a series of such compounds has been obtained and studied for biological activity. In particular, 5,6-difluoro-2-cyanobenzimidazole (II) was synthesized for the first time using the reaction of 1,2-diamino-4,5-difluorobenzole (I) with cyanoacetic ether. Pyrido[1,2-a]benzimidazoles (III, IV) were obtained via condensation of benzimidazole II with diethylethoxymethylene malonate and ethyl acetoacetate. The synthesized pyrido[1,2-a]benzimidazoles (III–XIII) were subjected to screening on a culture of Vero cells for antiviral activity and cytotoxicity with respect to ortho-poxviruses that are pathogenic for humans. ?? Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Kotovskaya, S. K.; Baskakova, Z. M.; Charushin, V. N.; Chupakhin, O. N.; Belanov, E. F.; Bormotov, N. I.; Balakhnin, S. M.; Serova, O. A.