Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Shchegol'kov E. V., Khudina O. G., Anikina L. V., Burgart Ya. V., Saloutin V. I. Заглавие : Synthesis, analgesic and antipyretic activity of 2-(antipyrin-4-yl)hydrazones of 1,2,3-triketones and their derivatives [Electronic resource] Место публикации : Pharmaceutical Chemistry Journal. - 2006. - Vol. 40, № 7. - С. 373-376 Систем. требования: http://www.springerlink.com/content/8137581016563700/fulltext.pdf Примечания : Библиогр. : с. 376 (10 назв.). - 1.11.2011 г. ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 1,2,3-Triketone 2-(antipyrin-4-yl)hydrazones were synthesized via the azo-coupling reactions of 1,3-diketones with 2-(antipyrin-4-yl)diazonium chloride. The fluoroalkyl-containing hetarylhydrazone enters into cyclocondensation with hydrazines at the 1,3-dicarbonyl fragment to yield 3-tetrafluoroethyl derivatives of pyrazole. It was found that 1,2,3-triketone 2-(antipyrin-4-yl)hydrazones and N-(2-hydroxyethyl)-substituted pyrazole exhibit analgesic activity comparable with that of their structural analog analgin (metamizole sodium), but do not possess antipyretic properties. In contrast, N-phenyl-substituted pyrazole did not exhibit analgesic properties but produced a certain antipyretic effect four hours after pyrogenic administration. Fluoroalkyl-containing compounds are less toxic substances than nonfluorinated 2-(antipyrin-4-yl)hydrazone and analgin. Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Shchegol'kov, E. V.; Khudina, O. G.; Anikina, L. V.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.