Вид документа : Статья из журнала Шифр издания : 54/D 62 Автор(ы) : Chupakhin O. N., Zyryanov G. V., Rusinov V. L., Krasnov V. P., Levit G. L., Koroleva M. A., Kodess M. I. Заглавие : Direct diastereoselective addition of l-menthol to activated 1,2,4-triazin-5(4H)-one Место публикации : Tetrahedron Letters. - 2001. - Vol. 42, № 12. - С. 2393-2395 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: For the first time in a triazine series it has been found that addition of a chiral O-nucleophile, l-menthol, to the C6-unsubstituted atom of 3-phenyl-1,2,4-triazin-5(4H)-one 1 activated by aliphatic acid anhydrides proceeds diastereoselectively to form a mixture of 1-acyl-6-[(1?R,3?R,4?S)-menthyl-3?)]-3-phenyl-(6S)-1,6-dihydro-1,2,4-triazin-5(4H)-ones 2 and 1-acyl-6-[(1?R,3?R,4?S)-menthyl-3?)]-3-phenyl-(6R)-1,6-dihydro-1,2,4-triazin-5(4H)-ones 3 in which the diastereomers 2 predominate. The diastereoselectivity of the process improves as the size of the N1-acyl substituent increases???? Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Chupakhin, O. N.; Zyryanov, G. V.; Rusinov, V. L.; Krasnov, V. P.; Levit, G. L.; Левит Галина Львовна; Koroleva, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович