Вид документа : Статья из журнала Шифр издания : 54/F 70 Автор(ы) : Kisil' S. P., Burgart Ya. V., Saloutin V. I., Chupakhin O. N. Заглавие : Fluoroaryl containing beta,beta-dioxoesters in the synthesis of fluorobenzopyran-4(2)-ones Место публикации : Journal of Fluorine Chemistry. - 2001. - Vol. 108, № 2. - С. 125-131 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluoroaryl containing ?,??-dioxoesters and their copper(II) chelates have been prepared by acylation of ethyl acetoacetate with 2,6-dimethoxy-3,4,5-trifluorobenzoyl, 2-methoxy-3,4,5,6-tetrafluorobenzoyl and pentafluorobenzoyl chlorides. Cyclization of these ?,??-dioxoesters leads to formation of substituted fluorochromones. Depending on conditions, 2-methyl-5-methoxy-6,7,8-trifluoro-3-ethoxycarbonylchromone hydrolyzed to 5-hydroxy-2-methyl-6,7,8-trifluorochromone or 5-hydroxy-2-methyl-6,7,8-trifluorochromone-3-carboxylic acid. The same chromone reacts with morpholine to form a seven-substituted product and ammonium hydroxide to give 3-iminoacetyl-4-hydroxy-5-methoxy-6,7,8-trifluorocoumarin. Hydrolysis of the latter affords 3-acetyl-4-hydroxy-5-methoxy-6,7,8-trifluorocoumarin. Ethyl-2-(2,6-dimethoxy-3,4,5-trifluorobenzoyl)-3-oxobutanoates undergoes ketone-splitting to 1-(2,6-dimethoxy-3,4,5-trifluorophenyl)-1,3-butandione???? Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Kisil', S. P.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Chupakhin, O. N.