Вид документа : Статья из журнала Шифр издания : 54/E 27 Автор(ы) : Krasnov V. P., Levit G. L., Bukrina I. M., Demin A. M., Chupakhin O. N., Ji Uk Yoo Заглавие : Efficient large (ca. 40 g) laboratory scale preparation of (S)- and (R)-valine tert-butyl esters Место публикации : Tetrahedron: Asymmetry . - 2002. - Vol. 13, № 17. - С. 1911-1914 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A large laboratory scale (ca. 40 g) method for the preparation of enantiomerically pure (S)- and (R)-valine tert-butyl esters has been developed. The method involves three steps: preparation of N-TFA-valines, preparation of valine tert-butyl esters using 2-methylpropene in dioxane in the presence of sulfuric acid, and isolation of the target compounds as the acetate derivative. The overall yield is up to 70% relative to the starting valine, ee being more than 98% (by HPLC)???? Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Krasnov, V. P.; Levit, G. L.; Левит Галина Львовна; Bukrina, I. M.; Demin, A. M.; Chupakhin, O. N.; Ji Uk Yoo