Вид документа : Статья из журнала Шифр издания : 54/A 19 Автор(ы) : Gruzdev D.A., Levit G. L., Krasnov V. P., Chulakov E.N., Sadretdinova L. Sh., Grishakov A. N., Ezhikova M. A., Kodess M. I., Charushin V. N. Заглавие : Acylative kinetic resolution of racemic amines using N-phthaloyl-(S)-amino acyl chlorides Место публикации : Tetrahedron: Asymmetry . - 2010. - Vol. 21, № 8. - С. 936-942 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A comparative study of the kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using N-phthaloyl-(S)-amino acyl chlorides as chiral acylating agents is described. Temperature and solvent effects on the stereochemical features have been examined. It has been found that N-phthaloyl-(S)-phenylalanyl and N-phthaloyl-(S)-2-phenylglycyl chlorides bearing aromatic substituents close to the stereogenic centre are more stereoselective acylating agents than N-phthaloyl-(S)-alanyl chloride. For the preparative kinetic resolution of racemic amines N-phthaloyl-(S)-phenylalanyl chloride proved to be the most appropriate chiral acylating agent Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Gruzdev, D.A.; Levit, G. L.; Левит Галина Львовна; Krasnov, V. P.; Chulakov, E.N.; Sadretdinova, L. Sh.; Grishakov, A. N.; Ezhikova, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович; Charushin, V. N.