Вид документа : Статья из журнала Шифр издания : 54/O-57 Автор(ы) : Khudina O. G., Burgart Ya. V., Saloutin V. I., Kravchenko M. A. Заглавие : One-pot synthesis of trifluoromethyl- and nitroso-substituted pyrazolines and pyrazoles and their tuberculostatic activity [Electronic resource] Место публикации : Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2010. - Vol. 59, № 10. - С. 1967-1973 Систем. требования: http://www.springerlink.com/content/l404530217824788/fulltext.pdf Примечания : Bibliogr. : p. 1973 (14 ref.). - 28.10.2011 г. ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 3-Trifluoromethyl-substituted 4-nitrosopyrazolines and 4-nitrosopyrazoles were prepared by a one-pot synthesis from trifluoromethyl-containing 1,3-diketones, sodium nitrite in acetic acid, and hydrazines (hydrazine hydrate, methylhydrazine). 3-Trifluoromethylpyrazolines can be converted to pyrazoles on heating. The use of phenylhydrazine in these reactions led to the formation of regioisomeric 4-hydroxyimino-5-(trifluoromethyl)pyrazoline. The structure of heterocycles synthesized was established using X-ray diffraction study, 1H and 19F NMR spectroscopy. The obtained products exhibited considerable tuberculostatic activity Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Khudina, O. G.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Kravchenko, M. A.