Вид документа : Статья из журнала Шифр издания : 54/O-57 Автор(ы) : Khudina O. G., Burgart Ya. V., Saloutin V. I., Kravchenko M. A. Заглавие : One-pot synthesis of 5-fluoroalkyl-5-hydroxy-4-hydroxy-imino-1-isonicotinoyl-4,5-dihydro-1H-pyrazoles and their tuberculostatic activity [Electronic resource] Место публикации : Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2011. - Vol. 47, № 6. - С. 904-909: ил. Систем. требования: http://www.springerlink.com/content/r2w746253417x244/fulltext.pdf Примечания : Bibliogr. : p. 909 (6 ref.). - 3.11.2011 г. ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: -Fluoroalkyl-5-hydroxy-4-hydroxyimino-1-isonicotinoyl-4,5-dihydro-1H-pyrazoles were synthesized via a one-pot procedure from polyfluoroalkyl-containing 1,3-diketones, sodium nitrite in acetic acid, and isoniazid. Acetylacetone gave rise to 3-hydroxyiminopentane-2,4-dione monoisonicotinoylhydrazone which underwent intramolecular cyclization to 5-hydroxy-4-hydroxyimino-1-isonicotinoyl-3,5-dimethyl-4,5-dihydro-1H-pyrazole on heating in ethanol. The synthesized compounds exhibited moderate tuberculostatic activity Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Khudina, O. G.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Kravchenko, M. A. |