Вид документа : Шифр издания : 54/S 98 Автор(ы) : Gruzdev D.A., Levit G. L., Kodess M. I., Krasnov V. P. Заглавие : Synthesis of enantiomers of 6-nitro- and 6-amino-2-methyl-1,2,3,4-tetrahydroquinolines Место публикации : Chemistry of Heterocyclic Compounds. - 2012. - Vol.48, №5. - С. 748-757 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): amides--diastereoisomers--enantiomers Аннотация: Enantiomers of 2-methyl-6-nitro-1,2,3,4-tetrahydroquinoline have been obtained by kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline in acylation with acyl chlorides of N-protected amino acids followed by regioselective nitration of the diastereoisomeric amides and acidic hydrolysis. The introduction of a trifluoroacetyl protecting group into the position 1 of the enantio pure nitro compound followed by the reduction led to (S)-6-amino-2-methyl-1-trifluoroacetyl-1,2,3,4-tetra-hydroquinoline in a high yield Доп.точки доступа: Gruzdev, D.A.; Levit, G. L.; Левит Галина Львовна; Kodess, M. I.; Кодесс Михаил Исаакович; Krasnov, V. P.