Вид документа : Шифр издания : 54/S 98 Автор(ы) : Ivanova A. E., Khudina O. G., Burgart Ya. V., Saloutin V. I., Kravchenko M. A. Заглавие : Synthesis of polyfluoroalkyl-containing 1-(4-acetoxybutyl)- and 1-(4-hydroxybutyl)pyrazoles and their tuberculostatic activity Место публикации : Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №11. - С. 2396-2400 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): synthesis--pyrazoles--tuberculostatic activity Аннотация: Alkylation of polyfluoroalkyl-containing pyrazoles with 4-bromobutyl acetate in acetone in the presence of potassium carbonate leads to a mixture of isomeric 1-(4-acetoxybutyl)-3-fluoroalkyl- and 1-(4-acetoxybutyl)-5-fluoroalkylpyrazoles, which in a number of cases were successfully separated by HPLC. Deacylation in acidic medium with gaseous hydrogen chloride and in basic medium with gaseous ammonia leads to 1-(4-hydroxybutyl)pyrazoles, which manifest moderate tuberculostatic activity Доп.точки доступа: Ivanova, A. E.; Khudina, O. G.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Kravchenko, M. A.