Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Kotovskaya S. K., Zhumabaeva G. A., Perova N. M., Baskakova Z. M., Charushin V. N., Chupakhin O. N., Belanov E. F., Serova O. A. Заглавие : Synthesis and antiviral activity of fluorinated 3-phenyl-1,2,4- benzotriazines Место публикации : Pharmaceutical Chemistry Journal. - 2007. - Vol.41, №2. - С. 62-68 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): cyclization--cytotoxicity--fluorination Аннотация: New synthetic approaches to fluorinated 3-phenyl-1,2,4-benzotriazines for biological testing have been elaborated. 1-(3,4-Difluorophenyl)-3,5- diphenylformazan (IVa) was synthesized via dinitriding of 3,4-difluoroaniline, followed by azo-addition of the resulting azobenzenediazonium chloride with acetaldehyde phenylhydrazone. 6,7-Difluoro-3-phenyl-1,2,4-benzotriazine (Va) was obtained via intramolecular cyclization of formazan IVa in the presence of BF3/AcOH complex. Monofluoro-substituted 6-R-7-fluoro-3-phenyl-1,2,4- benzotriazine derivatives (Vb-Vq) were prepared by substituting fluorine atom with alkoxides in 3,4-difluoronitrobenzene. Conditions for nucleophilic substitution of the second fluorine atom in benzotriazines V have been established. Fluorinated 3-phenyl-1,2,4-benzotriazines have been tested for antiviral and cytotoxic activity on Vero cell cultures and proved to be active against severe diseases caused by smallpox and some other pathogenic viruses Доп.точки доступа: Kotovskaya, S. K.; Zhumabaeva, G. A.; Perova, N. M.; Baskakova, Z. M.; Charushin, V. N.; Chupakhin, O. N.; Belanov, E. F.; Serova, O. A.