Вид документа : Статья из журнала Шифр издания : 54/G 65 Автор(ы) : Goryaeva M. V., Burgart Ya. V., Saloutin V. I. Заглавие : Peculiarities of cyclization of ethyl 2-ethoxymethylene-3-oxo-3- (polyfluoroalkyl)propionates with 3-amino-5-hydroxypyrazole Место публикации : Journal of Fluorine Chemistry. - 2013. - Vol.147. - С. 15-21 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 3-amino-5-hydroxypyrazole--recyclization--pyridines Аннотация: The reactions of ethyl 2-ethoxymethylene-3-oxo-3-(polyfluoroalkyl) propionates with 3-amino-5-hydroxypyrazole result in ethyl 2,7-dihydroxy-7- (polyfluoroalkyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-carboxylates under mild conditions. These products undergo recyclization in refluxing ethanol to form ethyl 3-hydroxy-4-(polyfluoroalkyl)-1H-pyrazolo[3,4-b]pyridin-5-carboxylates, whereas in refluxing glacial acetic acid they are dehydrated to ethyl 2-hydroxy-7-(polyfluoroalkyl)pyrazolo[1,5-a]pyrimidin-6-carboxylates. The non-fluorinated ethyl 2-ethoxymethylene-3-oxo esters in the reactions with 3-amino-5-hydroxypyrazole in ethanol (or glacial acetic acid) under reflux form only ethyl 2-hydroxy-7-phenyl(hydroxy)pyrazolo[1,5-a]pyrimidin-6-carboxylates Доп.точки доступа: Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.