Вид документа : Статья из журнала Шифр издания : 54/M 78 Автор(ы) : Shchegol'kov E. V., Ivanova A. E., Burgart Ya. V., Saloutin V. I., Chupakhin O. N. Заглавие : Modification of 2-trifluoromethyl-1H-benzimidazole with hydroxyalkyl substituents Место публикации : Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2013. - Vol.49, №3. - С. 417-420 Примечания : Библиогр.: с. 420 (7 ref.) ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 1h-benzimidazole --4-bromobutyl acetate--hydrogen chloride Аннотация: Alkylation of 2-(trifluoromethyl)-1H-benzimidazole with 4-bromobutyl acetate gave 4-[2-(trifluoromethyl)-1H-benzimidazol-1-yl]butyl acetate which was deacylated by the action of hydrogen chloride in anhydrous ethanol. 4-[2-(Trifluoromethyl)-1H-benzimidazol-1-yl]butan-1-ol thus formed showed a moderate tuberculostatic activity. Alkylation of the title compound with chloromethyloxirane afforded a mixture of 1-chloro-3-[2-(trifluoromethyl)-1H-benzimidazol-1-yl]-propan-2-ol and 1-(oxiran-2-ylmethyl)-2-trifluoromethyl-1H-benzimidazole. A new procedure was proposed for the synthesis of 2-[(2-trifluoromethyl-1Hbenzimidazol-1-yl)methoxy]ethyl acetate Доп.точки доступа: Shchegol'kov, E. V.; Ivanova, A. E.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Chupakhin, O. N. |