Вид документа : Статья из журнала Шифр издания : 54/A 10 Автор(ы) : Gruzdev D.A., Chulakov E.N., Levit G. L., Ezhikova M. A., Kodess M. I., Krasnov V. P. Заглавие : A comparative study on the acylative kinetic resolution of racemic fluorinated and non-fluorinated 2-methyl-1,2,3,4-tetrahydroquinolines and 3,4-dihydro-3-methyl-2H-[1,4]benzoxazines Место публикации : Tetrahedron: Asymmetry . - 2013. - Vol.24, №19. - С. 1240-1246 Примечания : Bibliogr. : p. 1246 (21 ref.) ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): racemic fluorinated --1,2,3,4-tetrahydroquinolines--benzoxazines Аннотация: The acylative kinetic resolution of racemic 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline, 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine, and their non-fluorinated analogues with (S)-naproxen and N-phthaloyl-(S)-amino acyl chlorides has been carried out. It has been shown that the presence of fluorine atoms in the aromatic fragment of a heterocyclic amine results in the increasing stereoselectivity of acylation with (S)-naproxen acyl chloride and in a decrease in the efficiency of acylative kinetic resolution using N-phthaloyl-(S)-amino acyl chlorides. A method for the preparation of enantiopure (S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (ee 99%) was developed Доп.точки доступа: Gruzdev, D.A.; Chulakov, E.N.; Levit, G. L.; Левит Галина Львовна; Ezhikova, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович; Krasnov, V. P.