Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Rodygin K. S., Rubtsova S.A., Slepukhin P. A., Kuchin A. V. Заглавие : Synthesis of new fluorine-containing pyrazolo[3,4-b]pyridinones Место публикации : Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №4. - С. 733-745 Примечания : Bibliogr. : p. 745 (28 ref.) ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): microwave irradiation--aminopyrazoles--arylsulfanyl(difluoro)methyl group Аннотация: Methods for the synthesis of 4 R 6,7 dihydro 1H pyrazolo[3,4 b]pyridin 6 ones (R = CF2SAr and 4 CFHSAr) were developed. The derivatives with R = CF2SAr were ob tained by both heterocyclization of 1 substituted 5 aminopyrazoles with ethyl 4,4 difluoro 3 oxo 4 phenylsulfanylbutanoate and replacement of the Br atom in 4 bromodifluoromethyl 6,7 dihydro 1H pyrazolo[3,4 b]pyridin 6 ones by sodium arenethiolates. The fragment 4 CF HSAr was introduced by replacement of the Cl atom in 4 chlorofluoromethyl 6,7 dihydro 1H pyrazolo[3,4 b]pyridin 6 ones by sodium arenethiolates. Oxidation of 4 CF2SPh 6,7 dihydro 1H pyrazolo[3,4 b]pyridin 6 ones gave the corresponding sulfoxides; their structures were con firmed by X ray diffraction data Доп.точки доступа: Rodygin, K. S.; Rubtsova, S.A.; Slepukhin, P. A.; Kuchin, A. V.