Вид документа : Статья из журнала Шифр издания : 54/G 90 Автор(ы) : Gruzdev D.A., Levit G. L., Krasnov V. P. Заглавие : Acylative kinetic resolution of racemic heterocyclic amines using N-phthaloyl-(S)-amino acyl chlorides with alkyl side chains Место публикации : Tetrahedron: Asymmetry . - 2012. - Vol.23. - С. 1640-1646 Примечания : Bibliogr.: p. 1645-1646 (15 ref.) ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): heterocyclic amines --racemic amines--acyl chlorides Аннотация: A comparative study of the acylative kinetic resolution of racemic 2-methyl-1,2,3,4 tetrahydroquinoline and 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine using N-phthaloyl-(S)-amino acyl chlorides with alkyl side chains has been carried out. The influence of steric factors on the stereoselectivity of the acylation was demonstrated. The (S)-enantiomers of the heterocyclic amines (ee 99%) were obtained in good yields via a kinetic resolution protocol using N-phthaloyl-(S)-leucyl chloride Доп.точки доступа: Levit, G. L.; Левит Галина Львовна; Krasnov, V. P.