Вид документа : Статья из журнала Шифр издания : 54/N 10 Автор(ы) : Gruzdev D.A., Vakarov S. A., Levit G. L., Krasnov V. P. Заглавие : N-Tosyl-(S)-Prolyl Chloride in Kinetic Resolution of Racemic Heterocyclic Amines Место публикации : Chemistry of Heterocyclic Compounds. - 2014. - Article in Press. - С. 1-13 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): h-[1,4]benzoxazine--acylation--amines Аннотация: The kinetic resolution of racemic heterocyclic amines via acylation with N-tosyl-(S)-prolyl chloride was systematically investigated. It was established that racemic mixtures of aromatic amines could be resolved with high efficiency, while the acylation of 2- and 3-methylpiperidines occurred with low diastereoselectivity. A method for the preparation of enantiomerically pure (3 R)-7,8-difluoro-3-methyl-3,4-dihydro-2 H-[1,4]benzoxazine was developed Доп.точки доступа: Gruzdev, D.A.; Vakarov, S. A.; Levit, G. L.; Левит Галина Львовна; Krasnov, V. P.