Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Galaiko N. V., Nazarov A. V., Tolmacheva I. A., Slepukhin P. A., Vikharev Y. B., Maiorova O. A., Grishko V. V. Заглавие : Synthesis of Triterpene A-Condensed Azoles Место публикации : Chemistry of Heterocyclic Compounds. - 2014. - С. Article in Press ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): alfa-hydroximino ketones--1,2,3-triazoles--allobetulone Аннотация: Lupane and 18αH-oleanane α-hydroximino ketones were used to synthesize derivatives condensed at ring A with a substituted azole fragment, namely, C(2)-C(3)-fused oxazoles and 1,2,3-triazoles. Triterpene isoxazoles fused at the C(1)-C(2) bond are described for the first time. An optimized method was proposed for the synthesis of unsubstituted 1,2,3-triazoles, displaying cytotoxic activity (IC50 8.4-40.7 μM) relative to rhabdomyosarcoma, lung carcinoma, and MS melanoma cell lines. Доп.точки доступа: Galaiko, N. V.; Nazarov, A. V.; Tolmacheva, I. A.; Slepukhin, P. A.; Vikharev, Y. B.; Maiorova, O. A.; Grishko, V. V.