Вид документа : Статья из журнала Шифр издания : 54/F 97 Автор(ы) : Grishko V. V., Galaiko N. V., Tolmacheva I. A., Kucherov I. I. , Eremin V. F., Boreco E. I., Savinova O. V., Slepukhin P. A. Заглавие : Functionalization, cyclization and antiviral activity of A-secotriterpenoids [Электронный ресурс] Место публикации : European Journal of Medicinal Chemisrty. - 2014. - Vol. 83. - С. 601-608 Систем. требования: http://www.sciencedirect.com/science/article/pii/S0223523414000300 Примечания : 14.08.15 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): a-secotriterpenoids --betulin--18βh-glycyrrhetinic acid Аннотация: Triterpene derivatives with an α,β-alkenenitrile moiety in the five-membered ring A have been synthesized by nitrile anion cyclizations of 1-cyano-2,3-secotriterpenoids. Oxime-containing precursors, 2,3-secointermediates and five-membered ring A products of cyclizations were screened for in vitro antiviral activity against enveloped viruses – influenza A virus and human immunodeficiency virus type I (HIV-1). Lupane ketoxime and the 2,3-secolupane C-3 aldoxime which possess antiviral activities against both influenza A virus (EC50 12.9–18.2 μM) and HIV-1 (EC50 0.06 μM) were the most promising compounds. Доп.точки доступа: Grishko, V. V.; Galaiko, N. V.; Tolmacheva, I. A.; Kucherov, I. I. ; Eremin, V. F.; Boreco, E. I.; Savinova, O. V.; Slepukhin, P. A.