Вид документа : Статья из журнала Шифр издания : Г/N 89 Автор(ы) : Krasnov V. P., Zarubaev V. V., Gruzdev D., Vozdvizhenskaya O., Vakarov S. A., Musiyak V. V. , Chulakov E. N., Volobueva A. S., Sinegubova E. O., Ezhikova M. A., Kodess M. I., Levit G. L., Charushin V. N. Заглавие : Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity Место публикации : Chemistry of Heterocyclic Compounds. - 2021. - Vol. 57, № 4. - С. 498-504 УДК : Г Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 6-chloropurine--heterocyclic amines--antiviral activity--influenza a and b viruses Аннотация: A number of novel amides were synthesized by coupling of 6-[(9H-purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine is linked to position 6 of purine through a fragment of ɷ-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro. Purine derivatives have been shown to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine depend on the length of the linker fragment. Доп.точки доступа: Krasnov, V. P.; Zarubaev, V. V.; Gruzdev, D.; Vozdvizhenskaya, O.; Vakarov, S. A.; Musiyak, V. V. ; Chulakov, E. N.; Volobueva, A. S.; Sinegubova, E. O.; Ezhikova, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович; Levit, G. L.; Левит Галина Львовна; Charushin, V. N.