Вид документа : Статья из журнала Шифр издания : Г/S 98 Автор(ы) : Ostrovskii V.A., Danagulyan G. G., Nesterova O. M., Pavlyukova Y. N., Tolstyakov V. V., Zarubina O. S., Slepukhin P. A., Esaulkova Y. L., Muryleva A. A., Zarubaev V. V., Trifonov R. E. Заглавие : Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines Место публикации : Chemistry of Heterocyclic Compounds. - 2021. - Vol. 57, № 4. - С. 448–454 УДК : Г Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): pyrimidines--tetrazoles--biological activity--linkers Аннотация: Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine. Доп.точки доступа: Ostrovskii, V.A.; Danagulyan, G. G.; Nesterova, O. M.; Pavlyukova, Y. N.; Tolstyakov, V. V.; Zarubina, O. S.; Slepukhin, P. A.; Esaulkova, Y. L.; Muryleva, A. A.; Zarubaev, V. V.; Trifonov, R. E.