Вид документа : Статья из журнала Шифр издания : Г/S 98 Автор(ы) : Elkina N. A., Shchegolkov E. V., Burgart Ya. V., Saloutin V. I., Boltneva N. P., Serebryakova O. G., Lushchekina S. V., Makhaeva G. F. Заглавие : Synthesis of new efficient and selective carboxylesterase inhibitors based on adamantyl and citronellyl 4,4,4-trifluoro-2-arylhydrazonylidene-3-oxobutanoates Место публикации : Russian chemical bulletin. - 2021. - Vol. 70, № 3. - С. 567–572 ББК : Г Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 4,4,4-trifluoro-2-arylhydrazinylidene-3-oxobutanoates--natural alcohols--carboxylesterase--inhibitors--molecular docking Аннотация: A series of new adamantyl and citronellyl 4,4,4-trifluoro-2-arylhydrazinylidene-3-oxo-butanoates was synthesized. The synthesized compounds in nanomolar concentrations selectively inhibit carboxylesterase, while their activity is independent of the nature and position of the substituent in the aryl fragment, which is consistent with the molecular docking results. Доп.точки доступа: Elkina, N. A.; Shchegolkov, E. V.; Burgart, Ya. V.; Бургарт Янина Валерьевна; Saloutin, V. I.; Boltneva, N. P.; Serebryakova, O. G.; Lushchekina, S. V.; Makhaeva, G. F.