Вид документа : Статья из журнала Шифр издания : Автор(ы) : Agafonova N. A., Burgart Y. V., Gerasimova N. A., Evstigneeva N. P., Saloutin V. I. Заглавие : Alternative approaches to the synthesis of polyfluoroalkyl-containing 1-methyl-4-nitrosopyrazoles Место публикации : Russian chemical bulletin. - 2021. - Vol. 70, № 6. - С. 1135–1140 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 4,4,4-trifl uoro-3,3-dihydroxy-2-(hydroxyimino)butan-1-ones--polyfl uoroalkyl2-hydroxyimino-1,3-diketones--1-methyl-4-nitrosopyrazoles--mycostatic activity Аннотация: We studied different approaches to the synthesis of polyfluoroalkyl-containing 1-methyl-4-nitrosopyrazoles, which are based on the cyclization of 4,4,4-trifluoro-3,3-dihydroxy-2-hydroxyimino-1-R-butan-1-ones or 2-hydroxyimino-1,3-diketones with methylhydrazine and on a one-pot sequential treatment of 1,3-diketones with sodium nitrite and methylhydrazine. It was found that the regioselectivity of the formation of 1-methyl-4-nitrosopyrazoles is affected by the steric factors of 1,3-dicarbonyl reagents. The study of the mycostatic effect of 4-nitrosopyrazoles showed that the introduction of a bulky polyfluoroalkyl or tert-butyl substituent leads to a decrease in their activity. Доп.точки доступа: Agafonova, N. A.; Burgart, Y. V.; Бургарт Янина Валерьевна; Gerasimova, N. A.; Evstigneeva, N. P.; Saloutin, V. I.