Вид документа : Статья из журнала Шифр издания : Автор(ы) : Rammohan A., Zyryanov G. V. Заглавие : Minireview: Remdesivir, a prominent nucleotide/nucleoside antiviral drug Место публикации : Polycyclic aromatic compounds. - 2021. - Vol. 42, № 8. - С. 5824-5831 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): antiviral drug--nucleotide analogue--remdesivir Аннотация: Nucleotide analogues are the divergent scaffolds that are reliable potential therapeutic drugs to treat the wide range of diseases including viral infections. For instance, Remdesivir is a biologically important nucleotide analogue prodrug that can act as a key drug target for the diseases Ebola and COVID-19. Remdesivir is a structurally chiral aryloxy-phosphoramidate prodrug as it is metabolized into nucleoside triphosphate (active drug form) inside the cell through sequential reactions by ester mediated-hydrolysis. Thus, the current minireview focuses on the earlier reported synthetic approaches of key fragments of remdesivir and their developments to attain the scale-up yields of the drug for clinical/commercial applies. Further, this review serves as a template for the design and development of other complex organic molecules. Доп.точки доступа: Zyryanov, G. V.