Вид документа : Статья из журнала Шифр издания : Автор(ы) : Burgart Y. V., Shchegolkov E. V., Shchur I., Kopchuk D. S., Zyryanov G. V., Savchuk M. I., Saloutin V., Charushin V. N., Chupakhin O. N., Ulitko M., Gerasimova N., Evstigneeva N. Заглавие : Promising antifungal and antibacterial agents based on 5-aryl-2,2'-bipyridines and their heteroligand salicylate metal complexes: synthesis, bioevaluation, molecular docking Место публикации : Chemmedchem: chemistry enabling drug discovery. - 2022. - Vol. 17, № 3. - С. e202100577 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A series of new 5-aryl-2,2′-bipyridines and their (polyfluoro)salicylate metal complexes was synthesized. Their antimicrobial activity was evaluated in vitro against eight strains of dermatophytes, seven strains of Candida yeasts, eight strains of Gram-positive and two strains of Gram-negative bacteria. Using molecular docking, we proposed that anti-staphylococcal action proceeds through the inhibition mechanism of the leading compounds to S. aureus DNA gyrase GyrB. Доп.точки доступа: Burgart, Y. V.; Бургарт Янина Валерьевна; Shchegolkov, E. V.; Shchur, I.; Kopchuk, D. S.; Zyryanov, G. V.; Savchuk, M. I.; Saloutin, V.; Charushin, V. N.; Chupakhin, O. N.; Ulitko, M.; Gerasimova, N.; Evstigneeva, N.