Вид документа : Шифр издания : Автор(ы) : Basha N. H., Rekha T., Padmavathi V., Sravya G., Reddy N. B., Zyryanov G. V. Заглавие : Azolyl pyrimidines-synthesis and antimicrobial activity Место публикации : AIP conference proceedings. - 2022. - Vol. 2390. - Ст.020006 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): chemical compounds--pharmaceuticals--antimicrobials Аннотация: Amide unit is a privileged structural motif and is a constituent of proteins, natural products and pharmaceuticals. Amongst different heterocyclic scaffolds, azoles and pyrimidines are the prominent entities in pharmaceutical arena. The biopotency of these heterocycles have triggered to synthesize a variety of heteroaromatics – azoles linked with pyridines by amino acetamide group. The target molecules-azolylaminoacetamidopyrimidines were prepared by the reaction of methyl azolylglycinate with pyrimidinyl-2-amine in the presence of DMAP and triethylamine in dichloromethane under ultrasonication. The lead molecules were evaluated for antimicrobial activity. Nitro substituted 2-((4-(4-chlorofuran-2-yl)thiazole-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (9c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug Chloramphenicol. However, 9c and nitro substituted 2-((4-(4-chlorofuran-2-yl)-1H-imidazol-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (10c) showed antifungal activity on A. niger greater than the standard drug Ketoconazole. Доп.точки доступа: Basha, N. H.; Rekha, T.; Padmavathi, V.; Sravya, G.; Reddy, N. B.; Zyryanov, G. V.