Вид документа : Статья из журнала Шифр издания : Автор(ы) : Gruzdev D.A., Telegina A. A., Ol’shevskaya V. A., Andronova V. L., Galegov G. A., Zarubaev V. V., Levit G. L., Krasnov V. P. Заглавие : New nido-carborane-containing conjugates of purine: synthesis and antiviral activity Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 11. - С. 2375-2382 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ ХИМИЧЕСКИЕ НАУКИ Аннотация: New purine derivatives containing a nido-carborane fragment were synthesized by nucleophilic substitution of chlorine atom in 6-chloropurine and 2-amino-6-chloropurine under the action of nido-carborane-containing amines. Compounds with significant activity against the acyclovir-resistant strain of herpes simplex virus type 1, as well as with moderate activity against influenza viruses A and B, were discovered for the first time among the synthesized nido-carboranyl derivatives of purine. Доп.точки доступа: Gruzdev, D.A.; Telegina, A. A.; Ol’shevskaya, V. A.; Andronova, V. L.; Galegov, G. A.; Zarubaev, V. V.; Levit, G. L.; Левит Галина Львовна; Krasnov, V. P.