Вид документа : Статья из журнала Шифр издания : 54/N 52 Автор(ы) : Kharitonova M. I., Denisova A. O., Kayushin A. L., Konstantinova I. D., Miroshnikov A. I., Kotovskaya S. K., Charushin V. N., Andronova V. L., Galegov G. A. Заглавие : New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1 Место публикации : Bioorganic and Medicinal Chemistry Letters. - 2017. - Vol. 27, № 11. - С. 2484-2487 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): antiviral activity--benzimidazoles--fluorinated compounds--nucleoside phosphorylases--nucleosides--transglycosylation reaction Аннотация: Using the enzymatic transglycosylation reaction β-d-ribo- and 2′-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activity (selectivity index 32) against a wild strain of the herpes simplex virus type 1, as well as towards virus strains that are resistant to acyclovir, cidofovir, and foscarnet. We believe that this compound might be used for treatment of herpes infections in those cases, when acyclovir is not efficient. Доп.точки доступа: Kharitonova, M. I.; Denisova, A. O.; Kayushin, A. L.; Konstantinova, I. D.; Miroshnikov, A. I.; Kotovskaya, S. K.; Charushin, V. N.; Andronova, V. L.; Galegov, G. A.