Вид документа : Статья из журнала Шифр издания : 54/S 91 Автор(ы) : Levit G. L., Gruzdev D.A., Krasnov V. P., Chulakov E.N., Sadretdinova L. Sh., Ezhikova M. A., Kodess M. I., Charushin V. N. Заглавие : Substituent effect on the stereoselectivity of acylation of racemic heterocyclic amines with N-phthaloyl-3-aryl-(S)-alanyl chlorides Место публикации : Tetrahedron: Asymmetry . - 2011. - Vol. 22, № 2. - С. 185-189 Примечания : Bibliogr. : p. 189 (17ref.) ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The acylative kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using acyl chlorides of N-phthaloyl-(S)-phenylalanine, N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine and N-phthaloyl-O-methyl-(S)-tyrosine as chiral resolving agents has been carried out. It is shown that the effectiveness of an acylative kinetic resolution depends on the electronic effects of substituents in the phenyl fragment of the acylating agent and increases as the electron-donating properties of the para-substituent (OMe H NO2) in phenyl fragment of N-phthaloyl-3-aryl-(S)-alanyl chlorides increase; conducting the process at a reduced temperature also contributes to an enhancement of the kinetic resolution Держатели документа: Центральная научная библиотека УрО РАН Доп.точки доступа: Levit, G. L.; Левит Галина Львовна; Gruzdev, D.A.; Krasnov, V. P.; Chulakov, E.N.; Sadretdinova, L. Sh.; Ezhikova, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович; Charushin, V. N.