Вид документа : Статья из журнала Шифр издания : 54/F 70 Автор(ы) : Pokrovskii A. G., Il"ichyova E.A., Kotovskaya S. K., Romanova S. A., Charushin V. N., Chupakhin O. N. Заглавие : Fluorinated derivatives of benz[4,5]imidazo[2,1-b][1,3]thiazoles are inhibitors of measles viruses Место публикации : Doklady Akademii Nauk . - 2004. - Vol.398, №3. - С. 412-414 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): antiviral activity--cytotoxicity--fluorinated benzimidazoles Аннотация: The results of in vitro anti-virus activity investigation for the new benzimidazoles (their synthesis is reported previously) are presented. The activity of the most active compound was studied in dependence of its introduction to the culture (before virus adsorption, simultaneously with virus, directly after virus adsorption, after 6 hours and after 1 day). Preliminary treatment of cells didn't protect them from further infecting; therewith the compound introduction simultaneously with virus or after infection caused no considerable effect on its anti-virus activity. The latter is attributed to blocking of late stages of measles virus reproduction - synthesis or arrangement of virus proteins Доп.точки доступа: Pokrovskii, A. G.; Il"ichyova, E.A.; Kotovskaya, S. K.; Romanova, S. A.; Charushin, V. N.; Chupakhin, O. N. |