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1.
Инвентарный номер: нет.
   


   
    α-Fetoprotein influence on the conversion of naϊve T-helpers into memory T-cell effector subpopulations / S. A. Zamorina, V. P. Timganova, M. S. Bochkova [et al.] // Doklady Biological Sciences. - 2018. - Vol. 482, № 1. - P210-213
ББК 53
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: The effect of native á-fetoprotein (AFP) on the conversion of naive T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naive T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-ã by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

\\\\Expert2\\NBO\\Doklady Biological Sciences\\2018 V 482 P. 210-213.pdf
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2.
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   Z 86


    Zotova, N. V.
    Systemic inflammation: methodological approaches to identification of the common pathological process / N. V. Zotova, V. A. Chereshnev, E. Yu. Gusev // PLOS One. - 2016. - Vol. 11, № 5. - P. e0155138
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
MULTI-SYNDROME -- PATHOLOGICAL PROCESS
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers>500ng/ml, cortisol>1380 or <100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.

\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
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3.
Инвентарный номер: нет.
   
   R 95


    Yushkov, B. G.
    The important questions of regeneration theory / B. G. Yushkov, V. A. Chereshnev // Experimental and Computational Biomedicine : Russian conference with international participation in memory of professor Vladimir S. Markhasin. - 2016. - P14
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ

\\\\Expert2\\NBO\\статьи из сборников\\Experimental and Computational Biomedicine 2016. - P. 14.pdf
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4.
Инвентарный номер: нет.
   
   U 62


   
    Untreated HCV-coinfection in HIV-infected patients induces additional CD4+ T-lymphocyte deficiency due to mobilization of naive cells into immune response resulting in their regeneration failure / K. V. Shmagel, E. V. Saidakova, L. B. Korolevskaya [et al.] // IAS 2017 : 9th IAS conference on HIV Science : Abstract book. - Paris, 2017. - P241
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

\\\\Expert2\\NBO\\статьи из сборников\\Абстракт_ Париж-2017.pdf
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5.
Инвентарный номер: нет.
   
   T 84


   
    Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities / M. S. Kuyukina, I. B. Ivshina, T. A. Baeva [et al.] // New Biotechnology. - 2015. - V. 32., № 6. - P559-568. - Bibliogr. : p. 566-568 (82 ref.)
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNOLOGICAL ACTIVITIES -- TREHALOLIPIDS -- RHODOCOCCUS RUBBER
Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed.

\\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf
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6.
Инвентарный номер: нет.
   
   T67


   
    To preservation of the microbial biodiversity of a human organism / V. A. Chereshnev, A. A. Morova, M. V. Chereshneva, G. V. Ikonnikova // Microbial Diversity: current situation, conservation strategy and ecological aspects «COMID 96»: International Conference: abstracts. - Perm, 1996. - P. 156-157
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
МИКРОБИОЛОГИЯ МЕДИЦИНСКАЯ -- МИКРОБИОЛОГИЯ МЕДИЦИНСКАЯ (ВЫЖИВАНИЕ БАКТЕРИЙ)

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7.
Инвентарный номер: нет.
   
   T 44


   
    The use of profetal for correction of the stress-and trauma-induced changes in the immune response against a xenogeneic antigen in rats with a penetrating wound of the eye / V. A. Chereshnev, M. V. Chereshneva, R. R. Faizrakhmanov, T. V. Gavrilova // Doklady Biological Sciences. - 2007. - Vol. 417, № 1. - С. 420-422
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- PRODUCING CELL -- ERYTHROCYTE

\\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 417, N 1.P. 420.pdf
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8.
Инвентарный номер: нет.
   
   T 44


   
    The role of systemic inflammation in the formation of CD4+T cell deficiency in HIV/HCV coinfection / E. V. Saidakova, L. B. Korolevskaya, K. V. Shmagel [et al.] // International Journal of Rheumatic Diseasis. - 2014. - Vol. 17, Suppl. 2. - P17-18
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
INFLAMMATION -- COINFECTION -- CD4+T

\\\\expert2\\nbo\\International Journal of Rheumatic Diseases\\2014. V. 17, Suppl. 2. P. 17-18.pdf
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9.
Инвентарный номер: нет.
   
   T 44


   
    The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES
Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e

\\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf
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10.
Инвентарный номер: нет.
   
   T 44


   
    The level of cytokines and inflammatory markers under myelopidum inclusion in complex therapy of patients with penetrating eye injury / M. V. Chereshneva, V. V. Chuprina, T. V. Gavrilova [et al.] // Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - P159
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CYTOKINES -- MYELOPIDUM

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