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Общее количество найденных документов : 211
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1.
Инвентарный номер: нет.
   


   
    1,3,4-thiadiazine derivates – antioxidants and protein glycation blockers – for correction of experimental diabetes mellitus / V. V. Emelyanov, E. A. Savateeva, L. P. Sidorova [et al.] // Experimental and Computational Biomedicine : Russian conference with international participation in memory of professor Vladimir S. Markhasin. - Ekaterinburg, 2016. - P65
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
1,3,4-THIADIAZINE -- ANTIOXIDANTS -- DIABETES MELLITUS

\\\\Expert2\\NBO\\статьи из сборников\\Experimental and Computational Biomedicine 2016. - P. 65.pdf
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2.
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    2-Thiomorpholino-5-aryl-6 H-1,3,4-thiadiazine hydrobromides and their ability to inhibit nonenzymatic protein glycosylation / L. P. Sidorova, T. A. Tseitler, V. V. Emel’yanov [et al.] // Pharmaceutical Chemistry Journal. - 2017. - Vol. 51, № 1. - P9-12
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
GLYCOSYLATION -- ESTERIFICATION -- GLYCOSYL COMPOUNDS -- DEGLYCOSYLATION -- ?-HALOGENACETOPHENONES -- 1,3,4-THIADIAZINE -- 4-MORPHOLINE THIOSEMICARBAZIDES -- CYCLOCONDENSATION -- NONENZYMATIC PROTEIN GLYCOSYLATION
Аннотация: Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.

\\\\Expert2\\NBO\\Pharmaceutical Chemistry Journal\\2017 v.51 p.9-12.pdf
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3.
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   A 10


   
    A new approach to making autoprostheses for angioplasty / V. A. Chereshnev, B. G. Yushkov, N. V. Tyumentseva [et al.] // Doklady Biological Sciences. - 2006. - Vol. 408, № 1. - P211-213
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANGIOPLASTY -- ANIMAL -- AUTOTRANSPLANTATION

\\\\expert2\\nbo\\Doklady Biological Sciences\\2006. V. 408, N 1.P. 211-213.pdf
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4.
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   A 10


   
    A new experimental model of hemolitic anemia after butoxyethanol and the stady of its immunology / V. A. Chereshnev, P. V. Kosareva, L. V. Sivakova [et al.] // Perm medicine in the context of an international communicftion in science: book of abstracts of the scintific symposium in foreign languages with an international participation. - Perm, 2016. - P30
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNOLOGICAL ACTIVITIES -- IMMUNOLOGY

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5.
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   A 10


   
    A new experimental model of hemolytic anemia after butoxyethanol and the study of its immunology / V. A. Chereshnev, P. V. Kosareva, E. I. Samodelkin, L. V. Sivakova // Hellenic Journal of Nuclear Medicine. - 2014. - January-April. - P7-10. - Bibliogr. : p. 10 (12 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
RATS - AUTOIMMUNITY BUTOXYETHANOL -- HEMOLYTIC ANEMIA
Аннотация: 2-butoxyethanol (C6H14O2) is widely used in many industrial reagents; according to the in vitro data it was established that 2- butoxyethanol metabolites are strong haemolytic poisons. Ghanayem B.I., Sullivan Ch.A. (1993) investigated in vitro the effect of BE on the red blood cells of 10 species of mammals, including humans. In this study, the authors established the species specificity with regard to the development of hemolytic anemia under the effect of butoxyethanol [4]. In the context of the available data, creation of experimental model based on the introduction of animal butoxyethanol is taking place. Since the druginduced hemolytic anemia is formed at the adjacency of toxic and autoimmune forms, the study of immunology of any toxic anemia is of great interest. Objective: to develop a new experimental model of hemolytic anemia after butoxyethanol and to study its immunology. In conclusion, the proposed model of hemolytic anemia after butoxyethanol may be used in the experimental and preclinical studies. The intraperitoneal administration of butoxyethanol provokes an autoimmune response directed against own red blood cells. The intraperitoneal administration of butoxyethanol to experimental animals is accompanied by a reduction of the lymphoid tissue that corresponds to the appropriate response to stress in the central and peripheral organs of immunogenesis

\\\\expert2\\nbo\\Hellenic Journal of Nuclear Medicine\\2014. P. 7-10.pdf
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6.
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    A rat model of post-traumatic stress syndrome causes phenotype-associated morphological changes and hypofunction of the adrenal gland / V. Tseilikman, M. Komelkova, M. V. Kondashevskaya [et al.] // International journal of molecular sciences. - 2021. - Vol. 22. - Ст. 13235
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CPTSD -- GLUCOCORTICOIDS -- BEHAVIOR -- ADRENAL GLAND

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7.
Инвентарный номер: нет.
   
   A 10


   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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8.
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   A 18


   
    Acquired immune deficiencies at complex chemical loading / V. A. Chereshnev, V. A. Demakov, B. A. Bachmetyev, U. V. Mikulitch, L. M. Papulov, U. N. Paderin // Allergy. - 1992. - Vol. 47, № 12. - P122
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNE DEFICIENCIES

\\\\expert2\\nbo\\XV Congress\\1992 P. 129 Allergy Тезисы ВАЧ .pdf
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9.
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    Alpha-fetoprotein as a factor of differentiation and functional activity of myeloid-derived suppressor cells / K. Yu. Shardina, S. A. Zamorina, V. P. Timganova [et al.] // Bulletin of experimental biology and medicine. - 2023. - Vol. 175. - P535–543
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: We studied the role of alpha-fetoprotein (AFP) in regulation of differentiation and functional activity of human myeloid-derived suppressor cells (MDSC) in vitro. To obtain MDSC, CD11b+ cells were isolated from the peripheral blood of healthy donors followed by cytokine induction (IL-1β+GM-CSF) into the MDSC phenotype. The cell functions were assessed by the expression of indoleamine 2,3-dioxygenase (IDO) and arginase-1 (Arg1) and cytokine profile of the cell cultures. Native AFP did not affect the total number of MDSC and the percentage of polymorphonuclear MDSC (PMN-MDSC), but increased the number of monocytic MDSC (M-MDSC). AFP did not change the expression of Arg1, but in low concentrations (10 and 50 U/ml) increased the number of IDO-containing cells. AFP modulated the cytokine profile of CD11b+ cells: it reliably decreased the level of IL-19 (50 and100 U/ml) and showed a tendency to decrease the levels of IL-34, MMP-2, sCD163, CHI3L1, OPN and to increase the levels of IL-29, IL-32, APRIL, PTX3, and sTNF-R1. Thus, we have demonstrated a regulatory effect of native AFP at the level of MDSC generated from CD11b+ cells under conditions of cytokine induction in vitro.

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10.
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   A 41


   
    Alpha-fetoprotein immunotherapy as a stage of combined treatment of cancer patients / V. A. Chereshnev, S. Yu. Rodionov, N. V. Vasilyev, O. A. Orlov, V. A. Cherkassov // Voprosy Onkologii . - 2005. - Vol.51, №1. - P86-92
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- ANTIBODY -- APOPTOSIS
Аннотация: The paper discusses the preliminary findings on alpha-feto-protein (AFP) treatment of 58 patients with stage III-IV malignancies of different localizations.influence on neoplastic processes was registered in poorly differentiated cell tumors, nor were any immunological mechanisms of antitumor action triggered on. However, in moderately- and well-differentiated cell tumors, several foci of acute immune inflammation were induced. It is suggested that AFP is responsible for tumor cell apoptosis by freeing antigenic determinants from shielding antibodies via elimination of «immunological enhancement» of tumor growth.

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