Центральная Научная Библиотека УрО РАН

Вид документа :
Шифр издания : 61/E 27
Автор(ы) : Berkasova N. L. , Gavrilova T. V., Shilov Yu. I., Chereshneva M. V., Chereshnev V. A.
Заглавие : Effects of myelopeptides on immune response and morphometrical manifestations of inflammation in experimental penetrating wound of the eye
Место публикации : Bulletin of experimental biology and medicine. - 2008. - Vol. 145, № 3. - С. 341-343
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): myelopeptides--myelopid--penetrating wound of the eye
Аннотация: Myelopid and MP-1 myelopeptide increase the count of antibody-producing cells, reduced under the effect of injury and standard therapy, and do not modify the suppression of delayed hypersensitivity. Injections of myelopid and MP-3 together with standard drugs optimized the traumatic inflammation processes
\\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2008, v.145, N 3, p. 341.pdf
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Вид документа :
Шифр издания : 57/P 93
Автор(ы) : Chereshnev V. A., Shilov Yu. I., Gavrilova T. V., Usov V. V., Chereshneva M. V.
Заглавие : Proliferativeresponse of lymphocyte to pokeweed mitogen depends on the concentration of endogenous cortisol in the early post-traumatic period in patients with penetrating eye injury
Место публикации : Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 5. - С. 722-725
Примечания : Bibliogr. : p. 724-725 (15 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): lymphocytes--cortisol--penetrating eye injury
Аннотация: The intensity of lymphocyte proliferation in response to pokeweed mitogen depends on cortisol level in the peripheral blood in the early post-traumatic period of penetrating eye injury. Lymphocyte proliferation in 72- and 96-h cultures from patients with high levels of endo genous hormone was suppressed. In 120-h cultures, the intensity of proliferation remains unchanged. Lymphocyte blast transformation was increased in 120-h cultures from patients with normal cortisol concentration and remained unchanged in case of low cortisol level
\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 5, p. 722-725.pdf
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Вид документа : Статья из журнала
Шифр издания : 57/E 97
Автор(ы) : Chereshnev V. A., Gankovskaya L. V., Koval'chuk L. V., Chereshneva M. V., Gankovskaya O. A.
Заглавие : Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis
Место публикации : Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 2. - С. 236-239
Примечания : Bibliogr. : p. 239 (11 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): innate immunity--herpetic infection--keratitis
Аннотация: The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and beta-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus
\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 2, p. 236-239.pdf
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Вид документа : Статья из журнала
Шифр издания : 57/M 99
Автор(ы) : Chereshnev V. A., Gein S. V., Mazunina L. S., Gavrilova T. V., Chereshneva M. V.
Заглавие : Myelopeptides regulate the microbicidic and secretory activities of Innate immunity effectors
Место публикации : Doklady biochemistry and biophysics. - 2011. - Vol. 436, № 1. - С. 53-55
Примечания : Bibliogr. : p. 55 (9 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): myelopeptides--microbicidic--innate immunity
\\\\expert2\\NBO\\Doklady Biological Sciences\\2011. V. 436, N 1.P. 53-55.pdf
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Вид документа :
Шифр издания : Ч2/R 30
Автор(ы) : Bocharov G., Danilov A., Vassilevski Y., Marchuk G. I., Chereshnev V. A.
Заглавие : Reaction diffusion modelling of interferon distribution in secondary lymphoid organs
Место публикации : Mathematical modelling of natural phenomena. - 2011. - Vol. 6, № 7. - С. 13-26
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): systems--recirculation--lymphocytes
Аннотация: This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-alpha (IFN alpha) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFN alpha is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFN alpha is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry
\\\\expert2\\nbo\\Mathematical Modelling and Natural Phenomena\\2011. Vol.6, №7. С. 13-26.pdf
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Chereshnev V. A., Gein S. V., Baeva T. A., Galkina T. V., Ivshina I. B.
Заглавие : Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant
Место публикации : Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - С. 734-738
Ключевые слова (''Своб.индексиров.''): rhodococcus rubber--glycolipid biosurfactant--interleukin-10
Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells
\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf
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Вид документа : Статья из журнала
Шифр издания : 61/H 91
Автор(ы) : Bocharov G., Chereshnev V. A., Gainova I. C., Bazhan S., Bachmetyev B.
Заглавие : Human immunodeficiency virus infection: From biological observations to mechanistic mathematical modelling
Место публикации : Mathematical modelling of natural phenomena. - 2012. - Vol. 7, № 5. - С. 78-104
Примечания : Bibliogr. : p. 93-104 (275 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): host-pathogen interaction--immune system--human immunodeficiency
Аннотация: HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to 'dynamic' categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis
\\\\expert2\\NBO\\Mathematical Modelling and Natural Phenomena\\2012. V. 7, N 5. P. 78-104.pdf
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Вид документа : Статья из журнала
Шифр издания : 61/T 44
Автор(ы) : Chereshnev V. A., Chereshneva M. V., Shilov Yu. I., Medvedeva, S.Y., Khonina N. B., Shilov S. Yu., Gavrilova T. V.
Заглавие : The effect of polyoxidonium on immune response and morphological parameters of inflammation after experimental penetrating eye injury
Место публикации : Doklady Biological Sciences. - 2012. - Vol. 443, № 1. - С. 75-77
Примечания : Bibliogr. : p. 77 (10 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): azoximer bromide--dexamethasone--heterophile antigen
\\\\expert2\\NBO\\Doklady Biological Sciences\\2012. V. 443, N 1. P. 75-77.pdf
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Вид документа :
Шифр издания : 61/R 45
Автор(ы) : Alvarez M. A., Patricia Arbelae, Francisko Ignacio Bastos, Ben Berkhout, Basudev Bhattacharya, Bocharov G., Chereshnev V. A.
Заглавие : Research priorities for HIV/M. tuberculosis co-infection
Место публикации : Open Infectious Diseases Journal. - 2011. - Vol. 5, № 1. - С. 14-20
Примечания : Bibliogr. : p. 19-20 (40 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): aids/tb--priority areas--joint
Аннотация: This document summarizes priority areas for joint research and concerted actions to counteract the public health threat of AIDS/TB as identified within the European Support Action "EUCO-Net" funded under the 7th Framework Programme of the European Commission
\\\\expert2\\nbo\\The Open Infectious Diseases Journal\\2011. - Vol.5, №1. - С. 14-20.pdf
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10.

Вид документа :
Шифр издания : 61/A 10
Автор(ы) : Bocharov G., Züst R., Cervantes-Barragan L., Luzyanina T., Chiglintsev E., Chereshnev V. A., Volker Thiel, Ludewig B.
Заглавие : A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections.
Место публикации : PLOS pathogens. - 2010. - Vol. 6, № 7. - С. 1-15 : рис., a-табл.
Примечания : Bibliogr. : p. 14-15 (52 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antivirus agent--dendritic cell--allergy and immunology
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs
\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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11.

Вид документа : Статья из журнала
Шифр издания : 57/A 10
Автор(ы) : Chereshnev V. A., Yushkov B. G., Tyumentseva N. V., Medvedeva S. Yu., Khodakov V. V., Krokhin D. I., Mersaidov K. V.
Заглавие : A new approach to making autoprostheses for angioplasty
Место публикации : Doklady Biological Sciences. - 2006. - Vol. 408, № 1. - С. 211-213
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): angioplasty--animal--autotransplantation
\\\\expert2\\nbo\\Doklady Biological Sciences\\2006. V. 408, N 1.P. 211-213.pdf
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12.

Вид документа : Статья из журнала
Шифр издания : 57/I-58
Автор(ы) : Chereshnev V. A., Kevorkov N. N., Bakhmet'ev B. A., Shirshev S. V., Shilov Yu. I., Shmagel K. V., Demakov V. A., Rayev M. V., Korolevskaya L. B., Starkova E. A., Shirsheva I. V.
Заглавие : Industrial environment and the immune system
Место публикации : Clinical and Applied Immunology Reviews . - 2001. - Vol. 1, № 3-4. - С. 147-152
Примечания : Bibliogr. : p. 152 (15 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): anthropogenic pollution--ecological immunology--immune correction
Аннотация: Major issues of the new scientific field of ecological immunology are considered. The principles of carrying out the immunotoxicological examinations are studied by the example of long-term observations from the ecological-immunological monitoring of adults and children from the West Ural, and also by the experiments (field tests) with animals. The concept of secondary ecologically-dependent immune deficient state is formulated, and the means for immune correction, including prevention, therapy and rehabilitation of the immune system alterations, are addressed
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13.

Вид документа : Статья из журнала
Шифр издания : 61/P 32
Автор(ы) : Chereshnev V. A., Bocharov G., Bazhan S., Bachmetyev B., Gainova I. C., Likhoshvai V.
Заглавие : Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective
Место публикации : International Reviews of Immunology. - 2013. - Vol. 32, № 3. - С. 282-306
Примечания : Библиогр.: с. 305- 306 (80 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): disease pathogenesis--effective cure--multiscale model
Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host
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14.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/I-55
Автор(ы) : Chereshnev V. A., Tuzankina I. A., Phylimonkova N. N., Tarasevich T. N., Murzina M. M., Chuverova K. A., Pashnina I. A.
Заглавие : Immunomodulatory effects of delta-sleep inducing peptide
Место публикации : Abstracts 13-th International Congress of Immunology. - Rio de Janeiro, Brazil, 2007. - С. 418
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): пептиды --эффект иммуномодулирующий --дельта-сон
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15.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/I-69
Автор(ы) : Yurchenko L. N., Gusev E. Y., Chereshnev V. A., Zotova N. V., Kopalova J. A., Sukhanov V. A.
Заглавие : Integral indexes of cytocinemia as a means to estimate critical states
Место публикации : Cytokines and Inflammation : abstracts GTCbio’s 5- th conference, Breckenridge, Colorado, January 29-30 2007. - Breckenridge, 2007. - С. 55
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): critical states --cytocinemia--cellular immunity
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16.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/T 44
Автор(ы) : Chereshneva M. V., Chuprina V. V., Gavrilova T. V., Shylov Yu. I., Chereshnev V. A.
Заглавие : The level of cytokines and inflammatory markers under myelopidum inclusion in complex therapy of patients with penetrating eye injury
Место публикации : Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - С. 159
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): cytokines--myelopidum
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17.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/I-57
Автор(ы) : Gein S. V., Kuyukina M. S., Ivshina I. B., Baeva T. A., Chereshnev V. A.
Заглавие : In vitro immunomodulating properties of biosurfactant glicolipid complex in the rhodococcus rubber. The role of monocyte and cell adhesion
Место публикации : Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - С. 147
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): immunomodulating properties --glicolipid complex --monocytes
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18.

Вид документа : Статья из сборника (однотомник)
Шифр издания : Ч2/I-70
Автор(ы) : Baranova A. A., Emelyanov V. V., Zhuravleva E. Yu., Savateeva E. A., Maksimova N. E., Mochulskaya N. N., Kruzhalov A. V., Chereshnev V. A.
Заглавие : Investigation of radiation and chemical processes under radiation processing of food and pharmaceuticals
Место публикации : Иссык-кульская международная летняя школа по радиационной физике SCORPH-2013 : сборник докладов конференции посвященной 80-летию члена-корреспондента НАН КР А. А. Алыбакова. - Бишкек, 2013. - С. 108-111: табл.
Примечания : Bibliogr. : p. 111 (8 ref.)
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): radiation--chemical processes --pharmaceuticals
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shinwari K., Wu Y., Rehman H., Xiao N., Bolkov M., Tuzankina I., Chereshnev V.
Заглавие : In-silico assessment of high-risk non-synonymous SNPs in ADAMTS3 gene associated with Hennekam syndrome and their impact on protein stability and function
Место публикации : BMC Bioinformatics. - 2023. - Vol. 24. - Ст.251
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Hennekam Lymphangiectasia–Lymphedema Syndrome 3 (HKLLS3) is a rare genetical disorder caused by mutations in a few genes including ADAMTS3. It is characterized by lymphatic dysplasia, intestinal lymphangiectasia, severe lymphedema and distinctive facial appearance. Up till now, no extensive studies have been conducted to elucidate the mechanism of the disease caused by various mutations. As a preliminary investigation of HKLLS3, we sorted out the most deleterious nonsynonymous single nucleotide polymorphisms (nsSNPs) that might affect the structure and function of ADAMTS3 protein by using a variety of in silico tools. A total of 919 nsSNPs in the ADAMTS3 gene were identified. 50 nsSNPs were predicted to be deleterious by multiple computational tools. 5 nsSNPs (G298R, C567Y, A370T, C567R and G374S) were found to be the most dangerous and can be associated with the disease as predicted by different bioinformatics tools. Modelling of the protein shows it can be divided into segments 1, 2 and 3, which are connected by short loops. Segment 3 mainly consists of loops without substantial secondary structures. With prediction tools and molecular dynamics simulation, some SNPs were found to significantly destabilize the protein structure and disrupt the secondary structures, especially in segment 2. The deleterious effects of mutations in segment 1 are possibly not from destabilization but from other factors such as the change in phosphorylation as suggested by post-translational modification (PTM) studies. This is the first-ever study of ADAMTS3 gene polymorphism, and the predicted nsSNPs in ADAMST3, some of which have not been reported yet in patients, will serve for diagnostic purposes and further therapeutic implications in Hennekam syndrome, contributing to better diagnosis and treatment.
https://link.springer.com/article/10.1186/s12859-023-05361-6
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20.

Вид документа : Статья из журнала
Шифр издания : 61/E 27
Автор(ы) : Baeva T. A., Gein S. V., Kuyukina M. S., Ivshina I. B., Kochina O. A., Chereshnev V. A.
Заглавие : Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro
Место публикации : Bulletin of experimental biology and medicine. - 2014. - Vol. 157, № 2. - С. 238-242
Примечания : Bibliogr. : p. 242 (15 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): glycolipid--rhodococcus ruber--neutrophils
Аннотация: Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignifi cantly
\\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2014, v.157, N 2, p. 238-242.pdf
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Сиглы отделов ЦНБ УрО РАН

  бр.ф. - Бронированный фонд

  бф - Научно-библиографический отдел

  БХЛ - Фонд художественной литературы

  ИИиА -Фонд исторической литературы в ЦНБ УрО РАН

  ИМЕТ -Отдел ЦНБ в Институте металлургии УрО РАН

  кх - Отдел фондов (книгохранениe)

  МБА - Межбиблиотечный абонемент

  мф - Методический фонд

  ок - Отдел научной каталогизации

  оку - Отдел комплектования и учета

  орф - Обменно-резервный фонд

  пф - Читальный зал деловой и патентной информации

  рк - Фонд редкой книги

  ч/з - Главный читальный зал

  эр - Зал электронных ресурсов

Сиглы библиотек институтов и НЦ УрО РАН

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