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1.
Инвентарный номер: нет.
   
   A 10

   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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2.
Инвентарный номер: нет.
   
   A 53

   
    An extremal shift method for control of HIV infection dynamics / G. Bocharov, A. V. Kim, A. V. Krasovskii [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling . - 2015. - Vol. 30, № 1. - P11-25
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HIV INFECTION -- OPTIMAL OPEN-LOOP CONTROL -- EXTREMAL SHIFT METHOD
Аннотация: Optimal control problems for mathematical models describing HIV infection dynamics in a human body are considered in the paper. An overview of current approaches to solution of control problems for models of HIV dynamics is presented for techniques related to construction of optimal programme (open loop) or positional (feedback) controls for various criteria of control process quality and is based on the Pontryagin's maximum principle and the Bellman's theory of dynamic programming, respectively. In the framework of the theory of positional differential games of Krasovskii, there are constructive and efficient methods of synthesis of controls for different classes of dynamical systems. In this paper we present a formalization of a control problem for HIV infection considered as a corresponding positional differential game. The control algorithm based on the method of extremal shift is applied to the ODEs model of HIV infection. The numerical implementation of the extremal shift method is developed to construct the control taking the system to a neighbourhood of a given trajectory using the information on the dynamics of the guides or leaders.

\\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 1. P. 11-30.pdf
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3.
Инвентарный номер: нет.
   
   A 88

    Chereshnev, V. A.
    Assessing the economic efficiency of socially oriented government programs by simulation modeling methods / V. A. Chereshnev, A. V. Vasil'eva, B. A. Korobitsyn // Economic Analysis: Theory and Practice. - 2017. - Vol. 16, № 1. - P174-187
ББК 65
Рубрики: ЭКОНОМИКА. ЭКОНОМИЧЕСКИЕ НАУКИ

\\\\Expert2\\NBO\\Economic Analysis Theory and Practice\\2017 V 16 N 1 P. 174-187.pdf
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4.
Инвентарный номер: нет.
   

   
    Checking gene expression profile associated with IRF7 and UNC93B deficient patient peripheral blood mononuclear cells infected with pH1N1 influenza virus / K. Shinwari, G. Liu, M. A. Bolkov [et al.] // AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - Ст. 030089
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
VIRUSES -- MICROARRAYS -- GENOMICS
Аннотация: An innate immune defect is a defect in the innate immune response that reduces the response to infection, this can occurs in genes important for activation regulation and proliferation of the innate immune cells or pathways important for the function of innate immunity. The purpose of this study was to identify novel biomarkers of interferon Receptor 7 through bioinformatics analysis and elucidate the possible molecular mechanism. The GSE 66486 datasets containing microarray data from IRF7 and UNC93B patients and healthy controls were downloaded from the GEO database and analyzed by the GEO2R web tool to obtain different expressed genes (DEGs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI), and Biological Networks Gene Oncology tool (BiNGO) were then performed to elucidate the molecular mechanism of IRF7. A total of 490 DEGs were identified, of which 14 were hub genes, and involved in ribosome biogenesis, rRNA processing, gene expression, mRNA processing, nuclear lumen, intracellular non-membrane-bounded organelle, nucleoplasm, small-subunit processome, antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes. Antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes possibly form the basis of IRF7 or UNC93B disorders, while our study provides a list of genes and pathways that are disrupted in IRF7/UNC93B, which has the potential to be used in the clinic for diagnosis and targeted therapy of such disorders in future.

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5.
Инвентарный номер: нет.
   
   C 98

   
    Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: A comparative study [Electronic resource] / T. G. Sviridova, D. G. Deryabin, O. Cyganok, V. A. Chereshnev // Central European Journal of Immunology. - 2013. - Vol. 38, № 3. - P310-316. - Bibliogr. : p. 316 (21 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
5-N-DODECYL RESORCINOL -- CYTOTOXICITY -- APOPTOSIS
Аннотация: Small molecules originating from microbes (SMOMs) play a significant role in bacterial-bacterial communication and in interactions between bacteria and their hosts. The aim of this study is a comparative analysis of the cytotoxic activity to human granulocytes and monocytes of two structurally close SMOMs: N-dodecanoyl-L-homoserine lactone (C12-HSL) and 5-N-dodecyl resorcinol (C12-AR). Cell viability was determined by Trypan blue dye exclusion. To distinguish cell death mechanisms, both necrosis and apoptosis tests were carried out. Cells undergoing apoptosis were identified by caspase-3 activity and the level of histone-associated DNA fragments. To evaluate cell lysis, the lactate dehydrogenase release test was used. In addition, the SMOM's action on erythrocyte membrane stability was investigated. The investigated SMOMs in micromolar concentrations showed more dose-dependent cytotoxicity against granulocytes than monocytes, but they used different mechanisms to impinge on the cell death pathway. C12-HSL specifically induced apoptosis similar to the activity previously reported for 3-oxo-N-dodecanoyl-L- homoserine lactone that originated from Pseudomonas aeruginosa. In contrast, C12-AR induced fast cytolytic effects (necrosis) as shown by the release of cytoplasmic lactate dehydrogenase, and presumably were defined by cellular membrane destabilisation. Our data demonstrate that both C 12-HSL and C12-AR can eliminate key defence cells, which would otherwise participate in the destruction of pathogenic bacteria. These results reinforce the SMOMs bifunctionality concept that such bacterial molecules not only regulate bacterial-bacterial interactions but also break immune defences as a new and important mechanism of host evasion

\\\\expert2\\nbo\\Central European Journal of Immunology\\2013. Vol.38, №3. С. 310-316.pdf
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6.
Инвентарный номер: нет.
   

   
    Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes / Zihao Chen, Guojun Liu, Guoqing Liu [et al.]. - https://doi.org/10.1186/s41065-020-00165-7 // Hereditas. - 2021. - Vol. 158, № 1. - 12 p
Кл.слова (ненормированные):
CD8+ T CELLS -- MOLECULAR SUBTYPE -- IMMUNOTHERAPY
Аннотация: Immunotherapy, especially anti-PD-1, is becoming a pillar of modern muscle-invasive bladder cancer (MIBC) treatment. However, the objective response rates (ORR) are relatively low due to the lack of precise biomarkers to select patients. Herein, the molecular subtype, tumor mutation burden (TMB), and CD8+ T cells were calculated by the gene expression and mutation profiles of MIBC patients. MIBC immunotypes were constructed using clustering analysis based on tumor mutation burden, CD8+ T cells, and molecular subtypes. Mutated genes, enriched functional KEGG pathways and GO terms, and co-expressed network-specific hub genes have been identified. We demonstrated that ORR of immunotype A patients identified by molecular subtype, CD8+ T cells, and TMB is about 36% predictable. PIK3CA, RB1, FGFR3, KMT2C, MACF1, RYR2, and EP300 are differentially mutated among three immunotypes. Pathways such as ECM-receptor interaction, PI3K-Akt signaling pathway, and TGF-beta signaling pathway are top-ranked in enrichment analysis. Low expression of ACTA2 was associated with the MIBC survival benefit. The current study constructs a model that could identify suitable MIBC patients for immunotherapy, and it is an important step forward to the personalized treatment of bladder cancers.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Hereditas. - 2021. - Vol. 158, № 1.pdf
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7.
Инвентарный номер: нет.
   
   E 27

   
    Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells / // Patologicheskaia fiziologiia i èksperimental'naia terapiia. - 2012. - № 1. - P19-22
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
IL1B PROTEIN -- HUMAN -- IMMUNOLOGICAL ADJUVANT
Аннотация: Myelopeptides MP-3, MP-5, and MP-6 were found to suppress zymosan-induced production of reactive oxygen species by leukocytes both under one-way introduction and under pretreatment. All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells. TNF-alpha production under myelopeptide effect was lowered in cultures with 150 mkg/ml zymosan. Under pretreatment myelopeptides did not render effect on IL-1beta and TNF-alpha production, with the exception of single stimulating effect of MP-5 on IL-1beta level in spontaneous cultures. Using comparative analysis the difference in direction and expressivity of effects of various myelopeptides was not revealed that suggests the existence of common mechanism of action in this group of peptide bioregulators.

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8.
Инвентарный номер: нет.
   

   
    Gene expression and pathway analysis in patients with inborn error of TLRs and IL-IRs signaling using microarray data / K. Shinwari, G. Liu, M. Bolkov [et al.] // AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - P030088
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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9.
Инвентарный номер: нет.
   

   
    Graph theory for modelling and analysis of the human lymphatic system / R. Savinkov, D. Grebennikov, D. Puchkova [et al.] // Mathematics. - 2020. - Vol. 8. - Ст. 2236. - 18 p.
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ИММУНОЛОГИЯ -- СИСТЕМА ЛИМФАТИЧЕСКАЯ -- МОДЕЛИРОВАНИЕ МАТЕМАТИЧЕСКОЕ
Аннотация: The human lymphatic system (HLS) is a complex network of lymphatic organs linked

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Mathematics 2020, 8, 2236.pdf
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10.
Инвентарный номер: нет.
   
   I-34

   
    Identification of the immune subtype among muscle-invasive bladder cancer patients by multiple datasets / K. Shinwari, Z. Chen, Z. Liu Guojun [et al.] // Acta Medica Indonesiana. - 2022. - Vol. 54, № 1. - P62-71
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
MOLECULAR SUBTYPE -- IMMUNOTHERAPY -- MIBC
Аннотация: Background: Immunotherapies including PD-1/PD-L1 antibodies have been approved for the treatment of Muscle-invasive Bladder Cancer (MIBC) patients. However, immunotherapies could only be beneficial for about 20% MIBC patients. Thus, identification of the immune subtype is becoming increasingly important. This study aimed to explore the immune subtype by analyzing the gene expression profiles. Methods: A total of 6 datasets including (GSE13507, GSE31684, GSE32548, GSE32894, GSE69795, and TCGA-BLCA) were downloaded. The gene expression profiles from different datasets were combined since the batch effects were removed. We performed unsupervised clustering analysis to identify the immune subtype by the combined gene expression profiles. The tumor-infiltration levels of 22 immune cells, immune scores, and tumor purity were calculated, and the survival analysis was performed to investigate the prognosis difference between immune subtypes. The enriched pathways for each immune subtype were obtained. Results: We identified four novel immune subtypes (referred to S1, S2, S3, and S4) among MIBC patients. We found that S1 was enriched in immune scores had the best prognosis. In contrast, S3 was poor in immune scores and had the worst prognosis. Subtype S1, S2, S3, and S4 were enriched in immune-related pathways, extracellular matrix-related pathways, metabolism-related pathways, and cancer-related pathways, respectively. Conclusion: The current study suggests that the immune subtypes based on gene expression profiles could contribute to select the appropriate MIBC patient for immunotherapies.

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