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1.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/I-55
Автор(ы) : Chereshnev V. A., Bachmetyev B. A., Kevorkov N. N., Shilov Ju. I., Shirshev S. V., Raev M. B.
Заглавие : Immunologic criteria for the evaluation of the population state of heath at the expressed anthropogenic load
Место публикации : Sustainable development: System analysis in Ecology, 2nd conference: abstracts . - Sevastopol, 1996. - С. 180
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): anthropogenic load
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2.

Вид документа : Статья из журнала
Шифр издания : 57/M 39
Автор(ы) : Novoselov A. V., Lozhnikov A. B., Chereshnev V. A., Sergeev A. G., Kim A. V., Gusev E. Tu., Pimenov V. G.
Заглавие : Mathematical modelling of mutant accumulation kinetics in a cloned viral population
Место публикации : Russian Journal of Numerical Analysis and Mathematical Modelling. - 2004. - Vol. 19, № 4. - С. 293-304
Примечания : Bibliogr. : p. 304 (18 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): cells --linear equations--mathematical models
Аннотация: The aim of this paper was to construct the mathematical model of the kinetics of non-hemagglutinating mutant accumulation in the cloned population of hemagglutinating echovirus 11 and to verify the model adequacy by comparing the results of biological and numerical experiments
\\\\expert2\\NBO\\Russian Journal of Numerical Anal. and Math. Modelling\\2004. V. 19, N. 4. P. 293-304.pdf
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3.

Вид документа : Статья из журнала
Шифр издания : 57/P 32
Автор(ы) : Chereshnev V. A., Mazurov V. D., Yurchenko L. N., Gusev E. Yu., Kim A. V.
Заглавие : Pattern recognition method in medicine
Место публикации : Russian Journal of Numerical Analysis and Mathematical Modelling. - 2004. - Vol.19, № 4. - С. 281-292
Примечания : Bibliogr. : p. 292 (6 ref.)
ББК : 57
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): bayes method--learning diagnostics--neurons
Аннотация: In this paper we consider models of learning diagnostics by precedents using pattern recognition methods and adjustment of layered neural nets. We show that in this case the problem reduces to the construction of committee constructions generalizing the notion of the solution to the system of linear inequalities. The methods proposed are justified. These methods are applied to the problems of medical diagnostics and for modelling empirical regularities
\\\\expert2\\NBO\\Russian Journal of Numerical Anal. and Math. Modelling\\2004. V. 19, N. 4. P. 281-292.pdf
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4.

Вид документа : Статья из журнала
Шифр издания : 57/М 54
Автор(ы) : Черешнев В. А., Мазуров В. Д., Юрченко Л. Н., Гусев Е. Ю., Ким А. В.
Заглавие : Метод распознавания образов в медицине
Место публикации : Russian Journal of Numerical Analysis and Mathematical Modelling. - 2004. - Vol. 19, № 4. - С. 281-292
Примечания : Библиогр.: с. 292 (6 назв.)
ББК : 57
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): bayes method--learning diagnostics--neurons
Аннотация: In this paper we consider models of learning diagnostics by precedents using pattern recognition methods and adjustment of layered neural nets. We show that in this case the problem reduces to the construction of committee constructions generalizing the notion of the solution to the system of linear inequalities. The methods proposed are justified. These methods are applied to the problems of medical diagnostics and for modelling empirical regularities
\\\\expert2\\NBO\\Russian Journal of Numerical Anal. and Math. Modelling\\2004. V. 19, N. 4. P. 281-292.pdf
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5.

Вид документа :
Шифр издания : 57/S 54
Автор(ы) : Shmagel K. V., Chereshnev V. A.
Заглавие : Molecular bases of immune complex pathology
Место публикации : Biochemistry. - 2009. - Vol. 74, № 5. - С. 469-479
Примечания : Bibliogr. : p. 477-479 (126 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): immune complexes--complement--cr1 receptors
Аннотация: The binding of antigens with antibodies forms immune complexes in the body. Usually these complexes are eliminated by the system of mononuclear phagocytes without development of pathological changes. This review highlights principal mechanisms responsible for safe removal of immune complexes in primates and humans. Special attention is given to diseases known as "immune complex diseases", when antigen-antibody complexes induce inflammatory reactions. The review considers key experimental works that significantly contributed to current knowledge of etiology and pathogenesis of type III hypersensitivity. Some factors of the development of immune complex syndrome such as level of humoral immune response to antigen, isotype and affinity of forming antibodies, the amount of immune complexes, and the consequences of their interaction with the complement system and Fc-receptors are analyzed based on the molecular mechanisms involved. The review contains a retrospective analysis of the most significant scientific achievements in immune complex pathology investigation within the last 100 years
\\\\expert2\\NBO\\Biochemistry\\2009, v.74, p. 469-479.pdf
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6.

Вид документа :
Шифр издания : 61/I-60
Автор(ы) : Shavrin A. P., Khovaeva Y. V., Chereshnev V. A., Golovskoy B. V.
Заглавие : Inflammation markers in atherosclerosis development
Место публикации : Cardiovascular therapy and prevention. - 2009. - Vol. 8, № 3. - С. 13-15
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): congestive-heart-failure--tumor-necrosis-factor--dependent vasodilation
Аннотация: To study different inflammation markers at various stages of atherosclerosis progression. Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to Visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis was used to measure plasma levels of C-reactive protein, CRP (SeroELISA test system, Diagnostic Systems Laboratories, USA), and cytokines - tumor necrosis factor alpha (THF-alpha), interleukins 1, 4 and 8 (1L-1, 2, and 8) (Russian test systems, Cytokine company, St. Petersburg
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7.

Вид документа :
Шифр издания : 61/A 10
Автор(ы) : Bocharov G., Züst R., Cervantes-Barragan L., Luzyanina T., Chiglintsev E., Chereshnev V. A., Volker Thiel, Ludewig B.
Заглавие : A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections.
Место публикации : PLOS pathogens. - 2010. - Vol. 6, № 7. - С. 1-15 : рис., a-табл.
Примечания : Bibliogr. : p. 14-15 (52 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antivirus agent--dendritic cell--allergy and immunology
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs
\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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8.

Вид документа : Статья из журнала
Шифр издания : 61/E 27
Автор(ы) : Chereshnev V. A., Chereshneva M. V., Mazunina L. S., Gein S. V.
Заглавие : Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells
Место публикации : Patologicheskaia fiziologiia i èksperimental'naia terapiia. - 2012. - № 1. - С. 19-22
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): il1b protein--human--immunological adjuvant
Аннотация: Myelopeptides MP-3, MP-5, and MP-6 were found to suppress zymosan-induced production of reactive oxygen species by leukocytes both under one-way introduction and under pretreatment. All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells. TNF-alpha production under myelopeptide effect was lowered in cultures with 150 mkg/ml zymosan. Under pretreatment myelopeptides did not render effect on IL-1beta and TNF-alpha production, with the exception of single stimulating effect of MP-5 on IL-1beta level in spontaneous cultures. Using comparative analysis the difference in direction and expressivity of effects of various myelopeptides was not revealed that suggests the existence of common mechanism of action in this group of peptide bioregulators.
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9.

Вид документа : Статья из журнала
Шифр издания : 61/P 32
Автор(ы) : Chereshnev V. A., Bocharov G., Bazhan S., Bachmetyev B., Gainova I. C., Likhoshvai V.
Заглавие : Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective
Место публикации : International Reviews of Immunology. - 2013. - Vol. 32, № 3. - С. 282-306
Примечания : Библиогр.: с. 305- 306 (80 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): disease pathogenesis--effective cure--multiscale model
Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host
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10.

Вид документа : Статья из журнала
Шифр издания : 61/C 98
Автор(ы) : Sviridova T. G., Deryabin D. G., Cyganok O., Chereshnev V. A.
Заглавие : Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: A comparative study
Место публикации : Central European Journal of Immunology. - 2013. - Vol. 38, № 3. - С. 310-316
Примечания : Bibliogr. : p. 316 (21 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 5-n-dodecyl resorcinol--cytotoxicity--apoptosis
Аннотация: Small molecules originating from microbes (SMOMs) play a significant role in bacterial-bacterial communication and in interactions between bacteria and their hosts. The aim of this study is a comparative analysis of the cytotoxic activity to human granulocytes and monocytes of two structurally close SMOMs: N-dodecanoyl-L-homoserine lactone (C12-HSL) and 5-N-dodecyl resorcinol (C12-AR). Cell viability was determined by Trypan blue dye exclusion. To distinguish cell death mechanisms, both necrosis and apoptosis tests were carried out. Cells undergoing apoptosis were identified by caspase-3 activity and the level of histone-associated DNA fragments. To evaluate cell lysis, the lactate dehydrogenase release test was used. In addition, the SMOM's action on erythrocyte membrane stability was investigated. The investigated SMOMs in micromolar concentrations showed more dose-dependent cytotoxicity against granulocytes than monocytes, but they used different mechanisms to impinge on the cell death pathway. C12-HSL specifically induced apoptosis similar to the activity previously reported for 3-oxo-N-dodecanoyl-L- homoserine lactone that originated from Pseudomonas aeruginosa. In contrast, C12-AR induced fast cytolytic effects (necrosis) as shown by the release of cytoplasmic lactate dehydrogenase, and presumably were defined by cellular membrane destabilisation. Our data demonstrate that both C 12-HSL and C12-AR can eliminate key defence cells, which would otherwise participate in the destruction of pathogenic bacteria. These results reinforce the SMOMs bifunctionality concept that such bacterial molecules not only regulate bacterial-bacterial interactions but also break immune defences as a new and important mechanism of host evasion
\\\\expert2\\nbo\\Central European Journal of Immunology\\2013. Vol.38, №3. С. 310-316.pdf
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