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1.

Вид документа : Статья из журнала
Шифр издания : Ч2/Ч-46
Автор(ы) : Черешнев В. А., Раев М. Б.
Заглавие : Неинструментальное определение стрептококков группы А
Место публикации : Вестник Уральской медицинской академической науки. - 2008. - № 6. - С. 41-43
Примечания : Библиогр.: с. 43 (15 назв.)
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): стрептококки группы а --диагностика медицинская
Аннотация: The analytical system for the determination of the group-A streptococci (SGA) has been constructed. The designed diag-nosticum does not depend on hardware, i.e. it belongs to the group of so-called non-instrumental systems. The suggested pattern in realized based on the original conjugate (diagnostic reagent) that is synthesized on the basis of covalent binding of polyclonal antibodies against group-A streptococci with colloid carbon particles; this conjugate possesses the ability to bind specifically to appropriate ligand. Due to high absorbance of such conjugates in the visible light region it is possible to make direct visual determination of SGA in a sample under study. The reaction is manifested in a form of black dots on a solid phase working surface. The system could be arranged either in the form of direct determination or in a sandwich-test variant. Such analytical systems could be an efficient tool for dispensary, hospital, and pre-clinical testing including extreme clinical and epidemic situations, as well as these could be applied in different kits for home and field diagnostics
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 41-43.pdf
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2.

Вид документа : Статья из журнала
Шифр издания : 61/Ч-46
Автор(ы) : Черешнев В. А., Рыбина, Ирина Владимировна, Бейкин, Яков Борисович
Заглавие : Иммунологические и генетические факторы бесплодия у жителей Екатеринбурга
Место публикации : Аллергология и иммунология. - 2006. - Т. 7, № 2. - С. 230-234
Примечания : Библиогр.: с. 234 (22 назв.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): бесплодие--генетические факторы--иммунологические факторы
Аннотация: Investigation of the degree of HLA class I antigens sharing in couples with infertility, testing for anti-spermal antibodies in both partners, anti- phosfolipid and anti-HLA antibodies in women demonstrated the primary role of immunological factors. The chromosomal abnormalities are less important but have to be considered in determination of infertility causes.
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Аллергология и иммунология\\2006-Vol7-#2_pp230-234.pdf
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Черешнев В. А., Оникиенко С. Б., Земляной А. В., Абкин С. В.
Заглавие : Применение защитных белков теплового шока-70 для борьбы с COVID-19
Место публикации : Журнал инфектологии. - 2022. - Т. 14, № 2, Приложение 1: Материалы VIII Конгресса Евро-Азиатского общества по инфекционным болезням, Санкт-Петербург, 17-19 мая 2022. - С. 134-135
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): covid 19--коронавирус--шок тепловой--белки защитные
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations
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4.

Вид документа : Статья из журнала
Шифр издания : 61/Z 86
Автор(ы) : Zotova N. V., Chereshnev V. A., Gusev E. Yu.
Заглавие : Systemic inflammation: methodological approaches to identification of the common pathological process
Место публикации : PLOS One. - 2016. - Vol. 11, № 5. - С. P. e0155138
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): multi-syndrome--pathological process
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers500ng/ml, cortisol1380 or 100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.
\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
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5.

Вид документа : Статья из журнала
Шифр издания : 57/T 84
Автор(ы) : Kuyukina M. S., Ivshina I. B., Baeva T. A., Kochina O. A., Gein S. V., Chereshnev V. A.
Заглавие : Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities
Место публикации : New Biotechnology. - 2015. - V. 32., № 6. - С. 559-568
Примечания : Bibliogr. : p. 566-568 (82 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): immunological activities--trehalolipids--rhodococcus rubber
Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed.
\\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf
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6.

Вид документа : Статья из журнала
Шифр издания : 61/T 44
Автор(ы) : Chereshnev V. A., Lushkov B. G., Sumin M. N., Tyumentseva N. V., Khramtsova I. S., Danilova I. G.
Заглавие : The blood system and the organism adaptation to extreme factor
Место публикации : Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk . - 2004. - Vol.90, №10. - С. 1193-1202
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): hemoglobin--hematopoiesis--leukocyte
Аннотация: The formation of blood system adoptive reaction in many cases is defined by the type of action and the condition of hemopoietic inductive microenvironment: hemodynamics of hemopoietic tissue, functional conditions of bone marrow macrophages, mast cells and glycosaminoglycans content. The shift in hemodlobin fraction occurs in extreme conditions requiring an increased gas transport by the blood. In case of tissue lesion, lymphocytes stimulate their regeneration. Morphogenetic function of lymphoid cells may be alerted by immunomodulators. Blood cells participate in angiogenesis, and this property may be used for vessel grafts production
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7.

Вид документа : Статья из журнала
Шифр издания : 61/S 98
Автор(ы) : Sidorova L. P., Tseitler T. A., Perova N. M., Emel’yanov V. V., Savateeva E. A., Maksimova N. E., Mochul’skaya N. N., Chereshnev V. A., Chupakhin O. N.
Заглавие : Synthesis of new 1,3,4-thiadiazines capable of inhibiting nonenzymatic glycosylation of proteins
Место публикации : Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - С. 501-505
Примечания : Bibliogr. : p. 505 (12 ref.)
ББК : 61 + 54
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 1,3,4-thiadiazine --cyclocondensation--nonenzymatic glycosylation of proteins--thiosemicarbazides
Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing
\\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2015, 49 (8), 501-505.pdf
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8.

Вид документа : Статья из журнала
Шифр издания : Ч2/R 87
Автор(ы) : Rozental' O. M., Chereshnev V. A.
Заглавие : A normative model of balanced nature management
Место публикации : Russian Journal of Ecology. - 2010. - Vol. 41, № 4. - С. 356-363
Примечания : Bibliogr. : p. 363 (13 ref.)
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): measuring control--traceability--variability of controlled parameters
Аннотация: The risk of erroneous regulation in multilevel normative environmental chains, at the federal, regional, and lower levels, down to the corporate one, has been studied. This risk has been demonstrated to increase unacceptably rapidly in the framework of the existing system of "unconditional acceptance" of normative standards. To mend the situation, it is necessary to use the "conditional acceptance" model by regarding post hoc decisions made at higher levels as a priori ones at the next (lower) levels. A strategy of environmentally and economically balanced corporate regulation of nature management through minimization of the losses resulting from both excessive caution and breaching the existing regulations has been proposed. This system, combined with the European approach to nature conservation, requires that the "riskless" regulation should be abandoned and is expected to improve the parameters of nature management quality by three to four orders of magnitude
\\\\expert2\\NBO\\Russian Journal of Ecology\\2010. V. 41, N 4. P. 356-363.pdf
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9.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sobolevskaya P. A., Gvozdeckii A. N., Kudryavtsev I. V., Chereshnev V. A., Сhurilov L. P.
Заглавие : Role of proinflammatory cytokines in hashimoto's thyroiditis associated with psychiatric disorders
Место публикации : Medical Immunology. - 2023. - Vol. 25, № 5. - С. 1247-1252
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are talking about high concentrations cytokines, we mean systemic inflammation. The minimal or mediocre fluctuations in cytokines within the ranges that are characteristic of healthy status or normergic acute phase response in disease cannot be interpreted from the point of view of binary endocrinological logic. In the CNS, cytokines are able to influence on the neuroendocrine control of systemically regulated functions. It is also important that glial cells (astroglia, microglia) are capable of producing a number of cytokines and can affect neurons and develop behavioral changes. In addition, the ability of a number of cytokines outside the CNS itself to act on vagal afferents and through them to convey information to the CNS, affecting its state and functions, has been proven. It is reasonable to assume that minimal fluctuations in cytokine levels may also affect the state and function of the CNS. The aim of the study was to investigate the levels of cytokines in patients with thyroiditis; in patients with thyroiditis associated with mental disorders; in a group of healthy individuals; and evaluate the effect of cytokine levels on clinical manifestations. In the group of patients with thyroiditis and mental disorders, the levels of CCL20/MIP3α, IL-13, IL-2, IL-27, IL-5 were significantly higher than in other groups. At the same time, no positive correlation was found between the clinical manifestations of mental disorders and the levels of cytokines. A positive correlation was found between the levels of some cytokines and free triiodothyronine, as well as the level of antithyroid antibodies. Mental disorders associated with autoimmune thyroiditis may be associated with changes in the cytokine profile and result from neuroinflammation.
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10.

Вид документа : Статья из журнала
Шифр издания : 61/P 32
Автор(ы) : Chereshnev V. A., Bocharov G., Bazhan S., Bachmetyev B., Gainova I. C., Likhoshvai V.
Заглавие : Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective
Место публикации : International Reviews of Immunology. - 2013. - Vol. 32, № 3. - С. 282-306
Примечания : Библиогр.: с. 305- 306 (80 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): disease pathogenesis--effective cure--multiscale model
Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host
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