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1.
Инвентарный номер: нет.
   

   
    Alpha-fetoprotein as a factor of differentiation and functional activity of myeloid-derived suppressor cells / K. Yu. Shardina, S. A. Zamorina, V. P. Timganova [et al.] // Bulletin of experimental biology and medicine. - 2023. - Vol. 175. - P535–543
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: We studied the role of alpha-fetoprotein (AFP) in regulation of differentiation and functional activity of human myeloid-derived suppressor cells (MDSC) in vitro. To obtain MDSC, CD11b+ cells were isolated from the peripheral blood of healthy donors followed by cytokine induction (IL-1β+GM-CSF) into the MDSC phenotype. The cell functions were assessed by the expression of indoleamine 2,3-dioxygenase (IDO) and arginase-1 (Arg1) and cytokine profile of the cell cultures. Native AFP did not affect the total number of MDSC and the percentage of polymorphonuclear MDSC (PMN-MDSC), but increased the number of monocytic MDSC (M-MDSC). AFP did not change the expression of Arg1, but in low concentrations (10 and 50 U/ml) increased the number of IDO-containing cells. AFP modulated the cytokine profile of CD11b+ cells: it reliably decreased the level of IL-19 (50 and100 U/ml) and showed a tendency to decrease the levels of IL-34, MMP-2, sCD163, CHI3L1, OPN and to increase the levels of IL-29, IL-32, APRIL, PTX3, and sTNF-R1. Thus, we have demonstrated a regulatory effect of native AFP at the level of MDSC generated from CD11b+ cells under conditions of cytokine induction in vitro.

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2.
Инвентарный номер: нет.
   
   C 36

   
    CD4+ T-cell cycling in hiv-infected patients with the discordant immunologic response to the antiretroviral therapy [Text] / E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya [et al.] // Cell and Tissue Biology. - 2019. - Vol. 13, № 1. - P55-63
ББК Р
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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3.
Инвентарный номер: нет.
   
   C 36

   
    CD8.sup.+ T cell expansion in HIV/HCV coinfection is associated with systemic inflammation / E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya [et al.] // Doklady Biological Sciences. - 2017. - Vol. 474, № 1. - P126-128
ББК 001.2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
HEPATITIS C -- RISK FACTORS -- COMORBIDITY -- RISK FACTORS -- T CELLS -- HEPATITIS C VIRUS
Аннотация: High prevalence of non-AIDS-defining illnesses in treated HIV-infected patients is associated with increased peripheral CD8.sup.+ T cell counts. Hepatitis C virus (HCV) coinfection is an additional risk factor for the development of non-AIDS events. We found that, in HIV/HCV coinfection, the increased proportion of CD8.sup.+ T lymphocytes is due to the effector memory and terminal effector T cells gain. Moreover, in these patients, the accumulation of highly differentiated forms of CD8.sup.+ T lymphocytes was associated with increased concentrations of inflammatory indices.

\\\\Expert2\\NBO\\Doklady Biological Sciences\\2017 v. 474 p. 126-128.pdf
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4.
Инвентарный номер: нет.
   

   
    Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes / Zihao Chen, Guojun Liu, Guoqing Liu [et al.]. - https://doi.org/10.1186/s41065-020-00165-7 // Hereditas. - 2021. - Vol. 158, № 1. - 12 p
Кл.слова (ненормированные):
CD8+ T CELLS -- MOLECULAR SUBTYPE -- IMMUNOTHERAPY
Аннотация: Immunotherapy, especially anti-PD-1, is becoming a pillar of modern muscle-invasive bladder cancer (MIBC) treatment. However, the objective response rates (ORR) are relatively low due to the lack of precise biomarkers to select patients. Herein, the molecular subtype, tumor mutation burden (TMB), and CD8+ T cells were calculated by the gene expression and mutation profiles of MIBC patients. MIBC immunotypes were constructed using clustering analysis based on tumor mutation burden, CD8+ T cells, and molecular subtypes. Mutated genes, enriched functional KEGG pathways and GO terms, and co-expressed network-specific hub genes have been identified. We demonstrated that ORR of immunotype A patients identified by molecular subtype, CD8+ T cells, and TMB is about 36% predictable. PIK3CA, RB1, FGFR3, KMT2C, MACF1, RYR2, and EP300 are differentially mutated among three immunotypes. Pathways such as ECM-receptor interaction, PI3K-Akt signaling pathway, and TGF-beta signaling pathway are top-ranked in enrichment analysis. Low expression of ACTA2 was associated with the MIBC survival benefit. The current study constructs a model that could identify suitable MIBC patients for immunotherapy, and it is an important step forward to the personalized treatment of bladder cancers.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Hereditas. - 2021. - Vol. 158, № 1.pdf
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5.
Инвентарный номер: нет.
   
   E 27

   
    Effect of hepatitis C vIrus coinfection on the content of CD4+ and CD8+ T cell subpopulations in HIV-infected patients receiving antiretroviral therapy / L. B. Korolevskaya, K. V. Shmagel, E. V. Saidakova [et al.] // Bulletin of experimental biology and medicine. - 2016. - Vol. 161, № 2. - P281-283. - Bibliogr. : p. 283 (12 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ--КЛИНИЧЕСКАЯ МЕДИЦИНА
Кл.слова (ненормированные):
HIV INFECTION -- HCV COINFECTION -- ANTIRETROVIRAL THERAPY -- T CELL SUBPOPULATIONS
Аннотация: We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2016, v.161, N 2, p. 281-283.pdf
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6.
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   F 33

   
    Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE
Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation

\\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf
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7.
Инвентарный номер: нет.
   

   
    In HIV-infected immunological non-responders, hepatitis C virus eradication contributes to incomplete normalization of systemic inflammation, but does not lead to rapid CD4+ T-cell count recovery / E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel [et al.] // Doklady Biochemistry and Biophysics. - 2023. - Vol. 512. - P274–278
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HIV INFECTIONS -- HEPATITIS C -- IMMUNOLOGICAL NON-RESPONSE
Аннотация: In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antivirals for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected INRs and relatively healthy volunteers. It was established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete.

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8.
Инвентарный номер: нет.
   
   I-60

   
    Influence of hepatitis C virus coinfection on CD4⁺ T cells of HIV-infected patients receiving HAART / K. V. Shmagel, E. V. Saidakova, L. B. Korolevskaya [et al.] // AIDS. - 2014. - Vol. 28, № 16. - P2381-2388. - Bibliogr. : p. 2388 (31 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
C VIRUS (HCV -- HIV
Аннотация: The effects of hepatitis C virus (HCV) coinfection on immune homeostasis and immune restoration in treated HIV infection are not well understood

\\\\Expert2\\NBO\\AIDS\\2014 V 28 N 16 P. 2381-2388.pdf
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9.
Инвентарный номер: нет.
   
   I-60

   
    Influens of hepatitis C virus coinfection on CD4+ T cell of HIV-infected patients receiving HAART / K. V. Shmagel, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, V. A. Chereshnev, D. D. Anthony, M. M. Lederman // AIDS. - 2014. - Vol. 28, № 16. - P2382-2388
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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10.
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    Lymphopenia-induced proliferation of CD4 T-cells is associated with CD4 T-lymphocyte exhaustion in treated HIV-infected patients / E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya [et al.] // Indian journal of medical research. - 2018. - Vol. 147, № 4. - P376-383
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

\\\\Expert2\\NBO\\Indian journal of medical research\\2018 Т.12 № 3 С. 233-237.pdf
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