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 Найдено в других БД:Каталог книг и продолжающихся изданий (25)Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН (8)Сводный каталог отечественных периодических изданий, имеющихся в библиотеках УрО РАН (1)Труды Института высокотемпературной электрохимии УрО РАН (34)Труды сотрудников Института органического синтеза УрО РАН (33)Труды сотрудников Института теплофизики УрО РАН (4)Труды сотрудников Института химии твердого тела УрО РАН (51)Расплавы (95)Публикации Чарушина В.Н. (12)Каталог библиотеки ИЭРиЖ УрО РАН (41)
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1.
Инвентарный номер: нет.
   
   A 10

   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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2.
Инвентарный номер: нет.
   

   
    Alpha-fetoprotein as a factor of differentiation and functional activity of myeloid-derived suppressor cells / K. Yu. Shardina, S. A. Zamorina, V. P. Timganova [et al.] // Bulletin of experimental biology and medicine. - 2023. - Vol. 175. - P535–543
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: We studied the role of alpha-fetoprotein (AFP) in regulation of differentiation and functional activity of human myeloid-derived suppressor cells (MDSC) in vitro. To obtain MDSC, CD11b+ cells were isolated from the peripheral blood of healthy donors followed by cytokine induction (IL-1β+GM-CSF) into the MDSC phenotype. The cell functions were assessed by the expression of indoleamine 2,3-dioxygenase (IDO) and arginase-1 (Arg1) and cytokine profile of the cell cultures. Native AFP did not affect the total number of MDSC and the percentage of polymorphonuclear MDSC (PMN-MDSC), but increased the number of monocytic MDSC (M-MDSC). AFP did not change the expression of Arg1, but in low concentrations (10 and 50 U/ml) increased the number of IDO-containing cells. AFP modulated the cytokine profile of CD11b+ cells: it reliably decreased the level of IL-19 (50 and100 U/ml) and showed a tendency to decrease the levels of IL-34, MMP-2, sCD163, CHI3L1, OPN and to increase the levels of IL-29, IL-32, APRIL, PTX3, and sTNF-R1. Thus, we have demonstrated a regulatory effect of native AFP at the level of MDSC generated from CD11b+ cells under conditions of cytokine induction in vitro.

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3.
Инвентарный номер: нет.
   
   A 41

   
    Alpha-fetoprotein immunotherapy as a stage of combined treatment of cancer patients / V. A. Chereshnev, S. Yu. Rodionov, N. V. Vasilyev, O. A. Orlov, V. A. Cherkassov // Voprosy Onkologii . - 2005. - Vol.51, №1. - P86-92
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- ANTIBODY -- APOPTOSIS
Аннотация: The paper discusses the preliminary findings on alpha-feto-protein (AFP) treatment of 58 patients with stage III-IV malignancies of different localizations.influence on neoplastic processes was registered in poorly differentiated cell tumors, nor were any immunological mechanisms of antitumor action triggered on. However, in moderately- and well-differentiated cell tumors, several foci of acute immune inflammation were induced. It is suggested that AFP is responsible for tumor cell apoptosis by freeing antigenic determinants from shielding antibodies via elimination of «immunological enhancement» of tumor growth.

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4.
Инвентарный номер: нет.
   

   
    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Preprints. - 2020. - 28 Oct. - Ст. 2020100591. - 27 p.
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Preprints 2020 Ст. 2020100591.pdf
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5.
Инвентарный номер: нет.
   

   
    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease : doi.org/10.3390/antib10010009 / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9.pdf
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6.
Инвентарный номер: нет.
   
   C 36

   
    CD4+ T-cell cycling in hiv-infected patients with the discordant immunologic response to the antiretroviral therapy [Text] / E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya [et al.] // Cell and Tissue Biology. - 2019. - Vol. 13, № 1. - P55-63
ББК Р
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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7.
Инвентарный номер: нет.
   
   C 36

   
    CD8.sup.+ T cell expansion in HIV/HCV coinfection is associated with systemic inflammation / E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya [et al.] // Doklady Biological Sciences. - 2017. - Vol. 474, № 1. - P126-128
ББК 001.2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
HEPATITIS C -- RISK FACTORS -- COMORBIDITY -- RISK FACTORS -- T CELLS -- HEPATITIS C VIRUS
Аннотация: High prevalence of non-AIDS-defining illnesses in treated HIV-infected patients is associated with increased peripheral CD8.sup.+ T cell counts. Hepatitis C virus (HCV) coinfection is an additional risk factor for the development of non-AIDS events. We found that, in HIV/HCV coinfection, the increased proportion of CD8.sup.+ T lymphocytes is due to the effector memory and terminal effector T cells gain. Moreover, in these patients, the accumulation of highly differentiated forms of CD8.sup.+ T lymphocytes was associated with increased concentrations of inflammatory indices.

\\\\Expert2\\NBO\\Doklady Biological Sciences\\2017 v. 474 p. 126-128.pdf
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8.
Инвентарный номер: нет.
   
   C 98

   
    Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: A comparative study [Electronic resource] / T. G. Sviridova, D. G. Deryabin, O. Cyganok, V. A. Chereshnev // Central European Journal of Immunology. - 2013. - Vol. 38, № 3. - P310-316. - Bibliogr. : p. 316 (21 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
5-N-DODECYL RESORCINOL -- CYTOTOXICITY -- APOPTOSIS
Аннотация: Small molecules originating from microbes (SMOMs) play a significant role in bacterial-bacterial communication and in interactions between bacteria and their hosts. The aim of this study is a comparative analysis of the cytotoxic activity to human granulocytes and monocytes of two structurally close SMOMs: N-dodecanoyl-L-homoserine lactone (C12-HSL) and 5-N-dodecyl resorcinol (C12-AR). Cell viability was determined by Trypan blue dye exclusion. To distinguish cell death mechanisms, both necrosis and apoptosis tests were carried out. Cells undergoing apoptosis were identified by caspase-3 activity and the level of histone-associated DNA fragments. To evaluate cell lysis, the lactate dehydrogenase release test was used. In addition, the SMOM's action on erythrocyte membrane stability was investigated. The investigated SMOMs in micromolar concentrations showed more dose-dependent cytotoxicity against granulocytes than monocytes, but they used different mechanisms to impinge on the cell death pathway. C12-HSL specifically induced apoptosis similar to the activity previously reported for 3-oxo-N-dodecanoyl-L- homoserine lactone that originated from Pseudomonas aeruginosa. In contrast, C12-AR induced fast cytolytic effects (necrosis) as shown by the release of cytoplasmic lactate dehydrogenase, and presumably were defined by cellular membrane destabilisation. Our data demonstrate that both C 12-HSL and C12-AR can eliminate key defence cells, which would otherwise participate in the destruction of pathogenic bacteria. These results reinforce the SMOMs bifunctionality concept that such bacterial molecules not only regulate bacterial-bacterial interactions but also break immune defences as a new and important mechanism of host evasion

\\\\expert2\\nbo\\Central European Journal of Immunology\\2013. Vol.38, №3. С. 310-316.pdf
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9.
Инвентарный номер: нет.
   
   D 44

   
    Dependence of the lymphocyte proliferative response on the endogenous cortisol level and sensitivity to β-adrenergic regulation in vitro in the early period of penetrating eye injury / V. A. Chereshnev, M. V. Chereshneva, Yu. I. Shilov, T. V. Gavrilova // Doklady Biological Sciences. - 2010. - Vol. 434, № 1. - P304-306. - Bibliogr. : p. 306 (10 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CELL PROLIFERATION -- DRUG EFFECT -- EYE INJURY

\\\\expert2\\NBO\\Doklady Biological Sciences\\2010. V. 434, N 1.P. 304-306.pdf
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10.
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   E 27

   
    Effect of hepatitis C vIrus coinfection on the content of CD4+ and CD8+ T cell subpopulations in HIV-infected patients receiving antiretroviral therapy / L. B. Korolevskaya, K. V. Shmagel, E. V. Saidakova [et al.] // Bulletin of experimental biology and medicine. - 2016. - Vol. 161, № 2. - P281-283. - Bibliogr. : p. 283 (12 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ--КЛИНИЧЕСКАЯ МЕДИЦИНА
Кл.слова (ненормированные):
HIV INFECTION -- HCV COINFECTION -- ANTIRETROVIRAL THERAPY -- T CELL SUBPOPULATIONS
Аннотация: We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2016, v.161, N 2, p. 281-283.pdf
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