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   Ф 24


    Фармакологическое регулирование программированной гибели клеток [] : монография / В. А. Черешнев, В. Н. Цыган, М. М. Одинак, А. М. Иванов ; редактор В. А. Черешнев ; Военно-медицинская академия. - Санкт-Петербург : Наука , 2011. - 253, [1] с. - Загл. на доп.тит.листе : Phrmacological regulation of programmed cell death. - Предм. указ.: с. 177-178. - Библиогр.: с. 179-248. - ISBN 978-5-02-037117-0 : Б. ц.

ГРНТИ

34.45

34.19

ББК Р281 + 570.5
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ--ФАРМАКОЛОГИЯ--ФАРМАЦИЯ--ТОКСИКОЛОГИЯ
БИОЛОГИЧЕСКИЕ НАУКИ--ОБЩАЯ БИОЛОГИЯ

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    Применение защитных белков теплового шока-70 для борьбы с COVID-19 / В. А. Черешнев, С. Б. Оникиенко, А. В. Земляной, С. В. Абкин // Журнал инфектологии. - 2022. - Т. 14, № 2, Приложение 1 : Материалы VIII Конгресса Евро-Азиатского общества по инфекционным болезням, Санкт-Петербург, 17-19 мая 2022. - С. 134-135
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
COVID 19 -- КОРОНАВИРУС -- ШОК ТЕПЛОВОЙ -- БЕЛКИ ЗАЩИТНЫЕ
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations

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    Влияние "профеталя"® на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева, Т. В. Гаврилова // Морфологические ведомости. - 2009. - Т. 1, № 1/2. - С. 68-70
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Морфологические ведомости\\2009. Т.1, №12. С. 68-70.pdf
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   В 58


    Влияние «Профеталя» на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева [и др.] // Морфологические ведомости. - 2009. - Т. 1, № 1-2. - С. 68-70. - Библиогр.: с. 70 (15 назв.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- ПРОНИКАЮЩЕЕ РАНЕНИЕ ГЛАЗА -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

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    α-Fetoprotein influence on the conversion of naϊve T-helpers into memory T-cell effector subpopulations / S. A. Zamorina, V. P. Timganova, M. S. Bochkova [et al.] // Doklady Biological Sciences. - 2018. - Vol. 482, № 1. - P210-213

ББК 53
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: The effect of native á-fetoprotein (AFP) on the conversion of naive T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naive T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-ã by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

\\\\Expert2\\NBO\\Doklady Biological Sciences\\2018 V 482 P. 210-213.pdf
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   Z 86

    Zotova, N. V.
    Systemic inflammation: methodological approaches to identification of the common pathological process / N. V. Zotova, V. A. Chereshnev, E. Yu. Gusev // PLOS One. - 2016. - Vol. 11, № 5. - P. e0155138

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
MULTI-SYNDROME -- PATHOLOGICAL PROCESS
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers>500ng/ml, cortisol>1380 or <100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.

\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
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   T 84


    Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities / M. S. Kuyukina, I. B. Ivshina, T. A. Baeva [et al.] // New Biotechnology. - 2015. - V. 32., № 6. - P559-568. - Bibliogr. : p. 566-568 (82 ref.)

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNOLOGICAL ACTIVITIES -- TREHALOLIPIDS -- RHODOCOCCUS RUBBER
Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed.

\\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf
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   T 44


    The use of profetal for correction of the stress-and trauma-induced changes in the immune response against a xenogeneic antigen in rats with a penetrating wound of the eye / V. A. Chereshnev, M. V. Chereshneva, R. R. Faizrakhmanov, T. V. Gavrilova // Doklady Biological Sciences. - 2007. - Vol. 417, № 1. - С. 420-422

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- PRODUCING CELL -- ERYTHROCYTE

\\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 417, N 1.P. 420.pdf
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   T 44


    The role of systemic inflammation in the formation of CD4+T cell deficiency in HIV/HCV coinfection / E. V. Saidakova, L. B. Korolevskaya, K. V. Shmagel [et al.] // International Journal of Rheumatic Diseasis. - 2014. - Vol. 17, Suppl. 2. - P17-18

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
INFLAMMATION -- COINFECTION -- CD4+T

\\\\expert2\\nbo\\International Journal of Rheumatic Diseases\\2014. V. 17, Suppl. 2. P. 17-18.pdf
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10.

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   T 44


    The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES
Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e

\\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf
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11.

Инвентарный номер: нет.

   T 10


    T cell apoptosis in HIV-infected patients with incomplete immune recovery after antiretroviral therapy [Electronic resource] / E. V. Saidakova, L. B. Korolevskaya, K. V. Shmagel, N. G. Shmagel, V. A. Chereshnev // Doklady Biological Sciences. - 2013. - Vol. 450, № 1. - P189-191. - Библиогр.: с. 191 (5 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIRETROVIRAL THERAPY -- HIV-INFECTED -- T CELL

\\\\expert2\\nbo\\Doklady Biological Sciences\\2013. V. 450, N 1. P. 189-191.pdf
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12.

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   S 54

    Shilov, Y. I.
    Influence of Blockade of β-Adrenoreceptors and Acute Stress on Antibody Formation, Delayed Type of Hypersensitivity, Phagocytic Cell Activity in Local Immune Response / Y. I. Shilov , S. V. Gein , V. A. Chereshnev // Russian Journal of Immunology. - 2001. - Vol. 6, № 3. - P. 301-308 : fig., tabl. - Bibliogr. : p. 308 (17 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
β-ADRENORECEPTORS -- ANTIBODY FORMATION -- HYPERSENSITIVITY -- PHAGOCYTIC CELL ACTIVITY

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Российский иммунологический журнал\\2001. - Vol. 6, № 3. - P. 301-308.PDF
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13.

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    SARS-Cov-2-specific immune response and the pathogenesis of Covid-19 / E. Gusev, A. Sarapultsev, L. Solomatina, V. Chereshnev // International journal of molecular sciences. - 2022. - Vol. 23, № 3. - Ст. 1716
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
КОРОНАВИРУС -- COVID 19 -- AUTOIMMUNITY -- ADAPTIVE IMMUNITY -- CELLULAR STRESS -- SARS-CoV-2;
Аннотация: The review aims to consolidate research findings on the molecular mechanisms and virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and their relevance to four typical stages in the development of acute viral infection. These four stages are invasion; primary blockade of antiviral innate immunity; engagement of the virus’s protection mechanisms against the factors of adaptive immunity; and acute, long-term complications of COVID-19. The invasion stage entails the recognition of the spike protein (S) of SARS-CoV-2 target cell receptors, namely, the main receptor (angiotensin-converting enzyme 2, ACE2), its coreceptors, and potential alternative receptors. The presence of a diverse repertoire of receptors allows SARS-CoV-2 to infect various types of cells, including those not expressing ACE2. During the second stage, the majority of the polyfunctional structural, non-structural, and extra proteins SARS-CoV-2 synthesizes in infected cells are involved in the primary blockage of antiviral innate immunity. A high degree of redundancy and systemic action characterizing these pathogenic factors allows SARS-CoV-2 to overcome antiviral mechanisms at the initial stages of invasion. The third stage includes passive and active protection of the virus from factors of adaptive immunity, overcoming of the barrier function at the focus of inflammation, and generalization of SARS-CoV-2 in the body. The fourth stage is associated with the deployment of variants of acute and long-term complications of COVID-19. SARS-CoV-2’s ability to induce autoimmune and autoinflammatory pathways of tissue invasion and development of both immunosuppressive and hyperergic mechanisms of systemic inflammation is critical at this stage of infection.

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14.

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   R 74


    Role of functional activity of phagocytic mononuclear system in the formation of autoprostheses for angioplasty [Electronic resource] / V. A. Chereshnev, N. V. Tyumentseva, B. G. Yushkov, I. G. Danilova, V. V, Khodakov, D. I. Krokhin, S. Yu. Medvedeva // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 2. - P217-218. - Bibliogr. : p. 218 (9 ref.)

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CARRAGEENAN -- PHAGOCYTIC MONONUCLEAR SYSTEM -- TAMERITE
Аннотация: The possibility of formation of connective-tissue vascular prostheses on subcutaneously implanted polychlorovynil base was demonstrated in experiments on rats. Suppression of the function of phagocytic cell with carrageenan decelerates, while its stimulation with tamerit accelerates the formation of connective-tissue autoprostheses.

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 2, p. 217.pdf
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15.

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   O-65


    Opportunmes of ripe dendritic cells with preparat containing humana-fetoprotein / O. V. Lebedinskaya, E. Lebedinskaya, T. V. Gavrilova [et al.] // The 12th International Symposium on Dendritic Cells, Daegu, Korea, 7-11 october 2012 : abstract. - Daegu, 2012. - P109

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
DENDRITIC CELL -- LEUKOCYTES -- FETOPROTEIN

\\\\expert2\\nbo\\12th Int. Symposium on Dendritic Cells\\2012. P01-40P. 109.pdf
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16.

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    Novel disease-associated missense single-nucleotide polymorphisms variants predication by algorithms tools and molecular dynamics simulation of human TCIRG1 gene causing congenital neutropenia and osteopetrosis / K. Shinwari, H. Rehman, H. Liu Guojun [et al.] // Frontiers in Molecular Biosciences. - 2022. - Vol. 9. - Ст. 879875
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: T Cell Immune Regulator 1, ATPase H + Transporting V0 Subunit A3 (TCIRG1 gene provides instructions for making one part, the a3 subunit, of a large protein complex known as a vacuolar H + -ATPase (V-ATPase). V-ATPases are a group of similar complexes that act as pumps to move positively charged hydrogen atoms (protons) across membranes. Single amino acid changes in highly conserved areas of the TCIRG1 protein have been linked to autosomal recessive osteopetrosis and severe congenital neutropenia. We used multiple computational approaches to classify disease-prone single nucleotide polymorphisms (SNPs) in TCIRG1. We used molecular dynamics analysis to identify the deleterious nsSNPs, build mutant protein structures, and assess the impact of mutation. Our results show that fifteen nsSNPs (rs199902030, rs200149541, rs372499913, rs267605221, rs374941368, rs375717418, rs80008675, rs149792489, rs116675104, rs121908250, rs121908251, rs121908251, rs149792489 and rs116675104) variants are likely to be highly deleterious mutations as by incorporating them into wild protein they destabilize the wild protein structure and function. They are also located in the V-ATPase I domain, which may destabilize the structure and impair TCIRG1 protein activation, as well as reduce its ATPase effectiveness. These mutants have not yet been identified in patients suffering from CN and osteopetrosis while (G405R, R444L, and D517N) reported in our study are already associated with osteopetrosis. Mutation V52L reported in our study was identified in a patient suspected for CN. Finally, these mutants can help to further understand the broad pool of illness susceptibilities associated with TCIRG1 catalytic kinase domain activation and aid in the development of an effective treatment for associated diseases.

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17.

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    Newborn Screening through TREC, TREC/KREC system for Primary Immunodeficiency with limitation of TREC/KREC. Comprehensive review / K. Shinwari, M. A. Bolkov, I. A. Tuzankina, V. A. Chereshnev // Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry. - 2021. - Vol. 20. - P132-149
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
PRIMARY iMMUNODEFICIENCY -- T-CELL LYMPHOPENIA
Аннотация: Newborn screening (NBS) by quantifying T cell receptor excision circles (TRECs) and Kappa receptor excision circles in neonatal dried blood spots (DBS) enables early diagnosis of different types of primary immune deficiencies. Global newborn screening for PID, using an assay to detect T-cell receptor excision circles (TREC) in dried blood spots (DBS), is now being performed in all states in the United States. In this review, we discuss the development and outcomes of TREC, TREC/KREC combines screening, and continued challenges to implementation.

\\\\nas3\\Nbo\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry. - 2021. - Vol. 20. - P. 132-149
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18.

Инвентарный номер: нет.



    Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant / V. A. Chereshnev, S. V. Gein, T. A. Baeva [et al.] // Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - P734-738
Кл.слова (ненормированные):
RHODOCOCCUS RUBBEr -- GLYCOLIPID BIOSURFACTANT -- INTERLEUKIN-10
Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf
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19.

Инвентарный номер: нет.

   M 45


    Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro [Electronic resource] / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 1. - P74-76. - Bibliogr. : p. 76 (7 ref.)

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
LYMPHOCYTE BLAST TRANSFORMATION -- MONOCYTES -- MYELOPEPTIDES
Аннотация: We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 1, p. 74.pdf
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20.

Инвентарный номер: нет.

   M 39


    Mathematical model of the Tat-Rev regulation of HIV-1 replication in an activated cell predicts the existence of oscillatory dynamics in the synthesis of viral components / V. Likhoshvai, T. Khlebodarova, S. Bazhan [et al.] // BMC Genomics. - 2014. - Vol. 15, Suppl. 12. - P1-18

ББК 57 + 61
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ --КЛИНИЧЕСКАЯ МЕДИЦИНА
Кл.слова (ненормированные):
HIV-1 REPLICATION -- OSCILLATORY DYNAMICS -- VIRAL COMPONENTS

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1-20 21-37

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